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Université de Fribourg

Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate

Filseck, Joachim Moser von ; Čopič, Alenka ; Delfosse, Vanessa ; Vanni, Stefano ; Jackson, Catherine L. ; Bourguet, William ; Drin, Guillaume

In: Science, 2015, vol. 349, no. 6246, p. 432–436

In eukaryotic cells, phosphatidylserine (PS) is synthesized in the endoplasmic reticulum (ER) but is highly enriched in the plasma membrane (PM), where it contributes negative charge and to specific recruitment of signaling proteins. This distribution relies on transport mechanisms whose nature remains elusive. Here, we found that the PS transporter Osh6p extracted phosphatidylinositol...

Université de Fribourg

Conformational proofreading of distant 40S ribosomal subunit maturation events by a long-range communication mechanism

Mitterer, Valentin ; Shayan, Ramtin ; Ferreira-Cerca, Sébastien ; Murat, Guillaume ; Enne, Tanja ; Rinaldi, Dana ; Weigl, Sarah ; Omanic, Hajrija ; Gleizes, Pierre-Emmanuel ; Kressler, Dieter ; Plisson-Chastang, Celia ; Pertschy, Brigitte

In: Nature Communications, 2019, vol. 10, no. 1, p. 2754

Eukaryotic ribosomes are synthesized in a hierarchical process driven by a plethora of assembly factors, but how maturation events at physically distant sites on pre- ribosomes are coordinated is poorly understood. Using functional analyses and cryo- EM, we show that ribosomal protein Rps20 orchestrates communication between two multi-step maturation events across the pre-40S subunit. Our...

Consortium of Swiss Academic Libraries

Changing concepts in plant hormone action

Gaspar, Th ; Kevers, C. ; Faivre-Rampant, O. ; Crèvecoeur, M. ; Penel, CL ; Greppin, H. ; Dommes, J.

In: In Vitro Cellular & Developmental Biology - Plant, 2003, vol. 39, no. 2, p. 85-106

Consortium of Swiss Academic Libraries

Regulation of phosphate transport in proximal tubules

Biber, J. ; Hernando, N. ; Forster, I. ; Murer, H.

In: Pflügers Archiv - European Journal of Physiology, 2009, vol. 458, no. 1, p. 39-52