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Consortium of Swiss Academic Libraries

The role of the acquired immune response in systemic sclerosis

Chizzolini, Carlo ; Boin, Francesco

In: Seminars in Immunopathology, 2015, vol. 37, no. 5, p. 519-528

Université de Fribourg

The role of TNFR2 and DR3 in the in vivo expansion of tregs in T cell depleting transplantation regimens

Rodriguez-Barbosa, Jose-Ignacio ; Schneider, Pascal ; Graca, Luis ; Bühler, Leo ; Perez-Simon, Jose-Antonio ; Rio, Maria-Luisa del

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 9, p. 3347

Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self and non-self through cell-intrinsic and cell-extrinsic mechanisms. Peripheral Tregs survival and clonal expansion largely depend on IL-2 and access to co-stimulatory signals such as CD28. Engagement of tumor necrosis factor receptor (TNFR) superfamily members, in particular TNFR2 and DR3, contribute to promote...

Université de Fribourg

Fine manual dexterity assessment after autologous neural cell ecosystem (ANCE) transplantation in a non-human primate model of parkinson’s disease

Borgognon, Simon ; Cottet, Jérôme ; Moret, Véronique ; Chatagny, Pauline ; Carrara, Laura ; Fregosi, Michela ; Bloch, Jocelyne ; Brunet, Jean-François ; Rouiller, Eric M. ; Badoud, Simon

In: Neurorehabilitation and Neural Repair, 2019, vol. 33, no. 7, p. 553–567

Autologous neural cell ecosystem (ANCE) transplantation improves motor recovery in MPTP monkeys. These motor symptoms were assessed using semi-quantitative clinical rating scales, widely used in many studies. However, limitations in terms of sensitivity, combined with relatively subjective assessment of their different items, make inter-study comparisons difficult to achieve. Objective. The...

Università della Svizzera italiana

T regulatory cells are markers of disease activity in multiple sclerosis patients

Dalla Libera, Dacia ; Di Mitri, Diletta ; Bergami, Alessandra ; Centonze, Diego ; Gasperini, Claudio ; Grasso, Maria Grazia ; Galgani, Simona ; Martinelli, Vittorio ; Comi, Giancarlo ; Avolio, Carlo ; Martino, Gianvito ; Borsellino, Giovanna ; Sallusto, Federica ; Battistini,Luca ; Furlan, Roberto

In: Plos one, 2011, vol. 6, no. 6, p. e21386

FoxP3+ Treg cells are believed to play a role in the occurrence of autoimmunity and in the determination of clinical recurrences. Contradictory reports are, however, available describing frequency and function of Treg cells during autoimmune diseases. We examined, by both polychromatic flow cytometry, and real-time RT-PCR, several Treg markers in peripheral blood mononuclear cells from...