In: International Journal of Legal Medicine, 2015, vol. 129, no. 5, p. 1079-1084
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In: Holzforschung, 2017, vol. 71, no. 5, p. 391-396
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In: Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, vol. 388, no. 12, p. 1283-1292
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In: Cellular and Molecular Life Sciences, 2015, vol. 72, no. 15, p. 2779-2792
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In: Scientific Reports, 2020, vol. 10, no. 1, p. 6072
Cell migration involves dynamic changes in cell shape. Intricate patterns of cell shape can be analyzed and classified using advanced shape descriptors, including spherical harmonics (SPHARM). Though SPHARM have been used to analyze and classify migrating cells, such classification did not exploit SPHARM spectra in their dynamics. Here, we examine whether additional information from dynamic...
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In: Frontiers in Oncology, 2020, vol. 10, p. -
The extracellular matrix (ECM) is a complex network composed of a multitude of different macromolecules. ECM components typically provide a supportive structure to the tissue and engender positional information and crosstalk with neighboring cells in a dynamic reciprocal manner, thereby regulating tissue development and homeostasis. During tumor progression, tumor cells commonly modify and...
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In: JoVE (Journal of Visualized Experiments), 2020, no. 159, p. e61090
A human alveolar cell coculture model is described here for simulation of the alveolar epithelial tissue barrier composed of alveolar epithelial type II cells and two types of immune cells (i.e., human monocyte-derived macrophages [MDMs] and dendritic cells [MDDCs]). A protocol for assembling the multicellular model is provided. Alveolar epithelial cells (A549 cell line) are grown and...
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In: Cells, 2020, vol. 9, no. 5, p. 1311
The roles and interactions of platelets and liver sinusoidal endothelial cells in liver regeneration are unclear, and the trigger that initiates hepatocyte proliferation is unknown. We aimed to identify the key factors released by activated platelets that induce liver sinusoidal endothelial cells to produce interleukin-6 (IL-6), a cytokine implicated in the early phase of liver regeneration....
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In: Journal of Cellular Physiology, 2020, p. jcp.29814
Elevated arginase type II (Arg‐II) associates with higher grade tumors. Its function and underlying molecular mechanisms in melanoma remain elusive. In the present study, we observed a significantly higher frequency of Arg‐II expression in melanoma of patients with metastasis than those without metastasis. Silencing Arg‐II in two human melanoma cell lines slowed down the cell growth,...
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In: Science Immunology, 2020, vol. 5, no. 46, p. eaaz4371
It is well established that tissue macrophages and tissue-resident memory CD8+ T cells (TRM) play important roles for pathogen sensing and rapid protection of barrier tissues. In contrast, the mechanisms by which these two cell types cooperate for homeostatic organ surveillance after clearance of infections is poorly understood. Here, we used intravital imaging to show that TRM dynamically...
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