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Plazomicin activity against polymyxin-resistant Enterobacteriaceae, including MCR-1-producing isolates

Denervaud-Tendon, Valérie ; Poirel, Laurent ; Connolly, Lynn E. ; Krause, Kevin M. ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2017, vol. 72, no. 10, p. 2787-2791

MASTER: a model to improve and standardize clinical breakpoints for antimicrobial susceptibility testing using forecast probabilities

Blöchliger, Nicolas

In: Journal of Antimicrobial Chemotherapy, ///-

Ampicillin-resistant Haemophilus influenzae isolates in Geneva: serotype, antimicrobial susceptibility, and β-lactam resistance mechanisms

Cherkaoui, A. ; Diene, S. ; Emonet, S. ; Renzi, G. ; Francois, P. ; Schrenzel, J.

In: European Journal of Clinical Microbiology & Infectious Diseases, 2015, vol. 34, no. 10, p. 1937-1945

Cross-border emergence of Escherichia coli producing the carbapenemase NDM-5 in Switzerland and Germany

Chakraborty, Trinad ; Sadek, Mustafa ; Yao, Yancheng ; Imirzalioglu, Can ; Stephan, Roger ; Poirel, Laurent ; Nordmann, Patrice

In: Journal of Clinical Microbiology, 2020, p. -

A series of clinical NDM-5-producing E. coli isolates obtained from two surveillance networks of carbapenem-producing Enterobacterales from 2018-2019, namely Switzerland (NARA) and Germany (SurvCARE), were analyzed. The 33 NDM-5- producing E. coli isolates were highly resistant to β-lactams including the novel ß- lactam/ß-lactamase inhibitor combinations (ceftazidime/avibactam, ...

Draft genome sequence of a blaNDM-1- and blaOXA-244-carrying multidrug-resistant Escherichia coli D-ST69 clinical isolate from Egypt

Soliman, Ahmed M. ; Ramadan, Hazem ; Sadek, Mustafa ; Nariya, Hirofumi ; Shimamoto, Toshi ; Hiott, Lari M. ; Frye, Jonathan G. ; Jackson, Charlene R. ; Shimamoto, Tadashi

In: Journal of Global Antimicrobial Resistance, 2020, vol. 22, p. 832–834

Objectives: This study describes the first draft genome sequence of a multidrug- resistant (MDR) Escherichia coli D-ST69 clinical isolate from Egypt carrying blaNDM-1 and blaOXA-244.Methods: The strain was isolated in December 2014 from a wound pus swab of a male patient in the city of Kafr El-Sheikh using MacConkey agar containing 2 μg/mL meropenem. The strain was subjected to antimicrobial ...

Characterization of FosL1, a plasmid-encoded fosfomycin resistance protein identified in Escherichia coli

Kieffer, Nicolas ; Poirel, Laurent ; Descombes, Marie-Christine ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2020, vol. 64, no. 4, p. -

Fosfomycin is gaining renewed interest for treating urinary tract infections. Monitoring fosfomycin resistance is therefore important in order to detect the emergence of novel resistance mechanisms. Here, we used the Rapid Fosfomycin NP test to screen a collection of extended-spectrum-β-lactamase- producing Escherichia coli isolates from Switzerland and found a fosfomycin- resistant isolate...

Full genome sequence of pT3, a multiresistant plasmid carrying the mcr-3.5 colistin resistance gene, recovered from an extended-spectrum-β-lactamase-producing Escherichia coli isolate from crickets sold as food

Zurfluh, Katrin ; Stevens, Marc J. A. ; Bucher, Melissa ; Poirel, Laurent ; Nordmann, Patrice ; Stephan, Roger

In: Microbiology Resource Announcements, 2019/8/29/e00647-19, /mra/8/29/MRA.00647-19.atom

Here, we sequenced multidrug resistance plasmid pT3, which encodes mcr-3.5 and other resistance genes. The cooccurrence of mcr genes and other resistance genes on a single plasmid is of concern.

Multifunctional nano‐biointerfaces: cytocompatible antimicrobial nanocarriers from stabilizer‐free cubosomes

Zabara, Mahsa ; Senturk, Berna ; Gontsarik, Mark ; Ren, Qun ; Rottmar, Markus ; Maniura-Weber, Katharina ; Mezzenga, Raffaele ; Bolisetty, Sreenath ; Salentinig, Stefan

In: Advanced Functional Materials, 2019, p. 1904007

The rational design of alternative antimicrobial materials with reduced toxicity toward mammalian cells is highly desired due to the growing occurrence of bacteria resistant to conventional antibiotics. A promising approach is the design of lipid‐based antimicrobial nanocarriers. However, most of the commonly used polymer‐stabilized nanocarriers are cytotoxic. Herein, the design of a...

Diarrheagenic enteroaggregative Escherichia coli causing urinary tract infection and bacteremia leading to sepsis

Herzog, K. ; Engeler Dusel, J. ; Hugentobler, M. ; Beutin, L. ; Sägesser, G. ; Stephan, R. ; Hächler, H. ; Nüesch-Inderbinen, M.

In: Infection, 2014, vol. 42, no. 2, p. 441-444

First report of an mcr-1-harboring Salmonella enterica subsp. enterica serotype 4,5,12:i:- strain isolated from blood of a patient in Switzerland

M.Carroll, Laura ; Zurfluh, Katrin ; Jang, Hyein ; Gopinath, Gopal ; Nüesch-Inderbinen, Magdalena ; Poirel, Laurent ; Nordmann, Patrice ; Stephan, Roger ; Guldimann, Claudia

In: International Journal of Antimicrobial Agents, 2018, vol. 52, no. 5, p. 740–741