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Consortium of Swiss Academic Libraries

Renormalized solutions to the continuity equation with an integrable damping term

Colombo, Maria ; Crippa, Gianluca ; Spirito, Stefano

In: Calculus of Variations and Partial Differential Equations, 2015, vol. 54, no. 2, p. 1831-1845

Université de Fribourg

Auxin-transporting ABC transporters are defined by a conserved D/E-P motif regulated by a prolylisomerase

Hao, Pengchao ; Xia, Jian ; Liu, Jie ; Donato, Martin Di ; Pakula, Konrad ; Bailly, Aurélien ; Jasinski, Michal ; Geisler, Markus

In: Journal of Biological Chemistry, 2020, vol. 295, no. 37, p. 13094–13105

The plant hormone auxin must be transported throughout plants in a cell-to-cell manner to affect its various physiological functions. ABCB transporters are critical for this polar auxin distribution, but the regulatory mechanisms controlling their function is not fully understood. The auxin transport activity of ABCB1 was suggested to be regulated by a physical interaction with FKBP42/Twisted...

Université de Fribourg

Granzyme B attenuates bacterial virulence by targeting secreted factors

López León, Diego ; Matthey, Patricia ; Fellay, Isabelle ; Blanchard, Marianne ; Martinvalet, Denis ; Mantel, Pierre-Yves ; Filgueira, Luis ; Walch, Michael

In: iScience, 2020, vol. 23, no. 3, p. 100932

Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to contribute crucially to antibacterial defense. Here we show that granzyme B degrades multiple secreted virulence mediators from Listeria monocytogenes,...

Università della Svizzera italiana

The role of smart meters in enabling real-time energy services for households : the Italian case

Pitì, Alessandro ; Verticale, Giacomo ; Rottondi, Cristina ; Capone, Antonio ; Lo Schiavo, Luca

In: Energies, 2017, vol. 10, no. 2, p. 199

The Smart Meter (SM) is an essential tool for successful balancing the demand-offer energy curve. It allows the linking of the consumption and production measurements with the time information and the customer’s identity, enabling the substitution of flat-price billing with smarter solutions, such as Time-of-Use or Real-Time Pricing. In addition to sending data to the energy operators for...

Università della Svizzera italiana

Long non-coding RNAs as molecular signatures for canine B-Cell lymphoma characterization

Cascione, Luciano ; Giudice, Luca ; Ferraresso, Serena ; Marconato, Laura ; Giannuzzi, Diana ; Napoli, Sara ; Bertoni, Francesco ; Giugno, Rosalba ; Aresu, Luca

In: Non-coding RNA, 2019, vol. 5, no. 3, p. 47

Diffuse large B-cell lymphoma (DLBCL), marginal zone lymphoma (MZL) and follicular lymphoma (FL) are the most common B-cell lymphomas (BCL) in dogs. Recent investigations have demonstrated overlaps of these histotypes with the human counterparts, including clinical presentation, biologic behavior, tumor genetics, and treatment response. The molecular mechanisms that underlie canine BCL are...

Université de Fribourg

HSP90 and co-chaperones: a multitaskers’ view on plant hormone biology

Donato, Martin di ; Geisler, Markus

In: FEBS Letters, 2019, vol. 593, no. 13, p. 1415–1430

In order to survive under ever‐changing conditions plants must be able to adaptively respond to their environment. Plant hormones and the signaling cross‐talk among them play a key role in integrating external and internal cues, enabling the plants to acclimate accordingly. HSP90 and several of its co‐chaperones are known as pleiotropic factors involved in the signaling pathways of...

Université de Fribourg

A novel Ca2+-binding protein that can rapidly transduce auxin responses during root growth

Hazak, Ora ; Mamon, Elad ; Lavy, Meirav ; Sternberg, Hasana ; Behera, Smrutisanjita ; Schmitz-Thom, Ina ; Bloch, Daria ; Dementiev, Olga ; Gutman, Itay ; Danziger, Tomer ; Schwarz, Netanel ; Abuzeineh, Anas ; Mockaitis, Keithanne ; Estelle, Mark ; Hirsch, Joel A. ; Kudla, Jörg ; Yalovsky, Shaul

In: PLOS Biology, 2019, vol. 17, no. 7, p. e3000085

Signaling cross talks between auxin, a regulator of plant development, and Ca2+, a universal second messenger, have been proposed to modulate developmental plasticity in plants. However, the underlying molecular mechanisms are largely unknown. Here, we report that in Arabidopsis roots, auxin elicits specific Ca2+ signaling patterns that spatially coincide with the expression pattern of...

Université de Fribourg

ABCG36/PEN3/PDR8 Is an Exporter of the Auxin Precursor, Indole-3-Butyric Acid, and Involved in Auxin-Controlled Development

Aryal, Bibek ; Huynh, John ; Schneuwly, Jerôme ; Siffert, Alexandra ; Liu, Jie ; Alejandro, Santiago ; Ludwig-Müller, Jutta ; Martinoia, Enrico ; Geisler, Markus

In: Frontiers in Plant Science, 2019, vol. 10, p. -

The PDR-type ABCG transporter, ABCG36/PDR8/PEN3, is thought to be implicated in the export of a few structurally unrelated substrates, including the auxin precursor, indole-3-butyric acid (IBA), although a clear-cut proof of transport is lacking. An outward facing, lateral root (LR) location for ABCG36 fuelled speculations that it might secrete IBA into the rhizosphere. Here, we provide...

Consortium of Swiss Academic Libraries

Pattern formation in auxin flux

Feller, C. ; Gabriel, J. ; Mazza, C. ; Yerly, F.

In: Journal of Mathematical Biology, 2014, vol. 68, no. 4, p. 879-909