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Università della Svizzera italiana

Non-alcoholic fatty liver disease : metabolic, genetic, epigenetic and environmental risk factors

Juanola, Oriol ; Martínez-López, Sebastián ; Francés, Rubén ; Gómez-Hurtado, Isabel

In: International journal of environmental research and public health, 2021, vol. 18, no. 10, p. 24

Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver disease in the Western world, probably due to the growing prevalence of obesity, metabolic diseases, and exposure to some environmental agents. In certain patients, simple hepatic steatosis can progress to non-alcoholic steatohepatitis (NASH), which can sometimes lead to liver cirrhosis and its...

Università della Svizzera italiana

Intestinal microbiota drives cholestasis-induced specific hepatic gene expression patterns

Juanola, Oriol ; Hassan, Mohsin ; Kumar, Pavitra ; Yilmaz, Bahtiyar ; Keller, Irene ; Simillion, Cédric ; Engelmann, Cornelius ; Tacke, Frank ; Dufour, Jean-François ; De Gottardi, Andrea ; Moghadamrad, Sheida

In: Gut microbes, 2021, vol. 13, no. 1, p. 20

Intestinal microbiota regulates multiple host metabolic and immunological processes. Consequently, any difference in its qualitative and quantitative composition is susceptible to exert significant effects, in particular along the gut-liver axis. Indeed, recent findings suggest that such changes modulate the severity and the evolution of a wide spectrum of hepatobiliary disorders. However, the...

Università della Svizzera italiana

Dietary chloride deficiency syndrome : pathophysiology, history, and systematic literature review

Signorelli, Giulia C. ; Bianchetti, Mario G. ; Jermini, Luca M. M. ; Agostoni, Carlo ; Milani, Gregorio P. ; Simonetti, Giacomo D. ; Lava, Sebastiano A. G.

In: Nutrients, 2020, vol. 12, no. 11, p. 10 p

Metabolic alkalosis may develop as a consequence of urinary chloride (and sodium) wasting, excessive loss of salt in the sweat, or intestinal chloride wasting, among other causes. There is also a likely underrecognized association between poor salt intake and the mentioned electrolyte and acid–base abnormality. In patients with excessive loss of salt in the sweat or poor salt intake, the...

Consortium of Swiss Academic Libraries

The intestinal microbiota: its role in health and disease

Biedermann, Luc ; Rogler, Gerhard

In: European Journal of Pediatrics, 2015, vol. 174, no. 2, p. 151-167

Université de Fribourg

Study protocol for the ABERRANT study: antibiotic-induced disruption of the maternal and infant microbiome and adverse health outcomes — a prospective cohort study among children born at term

Volery, Maryse ; Scherz, Valentin ; Jakob, William ; Bandeira, Diane ; Deggim-Messmer, Vanessa ; Lauber-Biason, Anna ; Wildhaber, Johannes ; Falquet, Laurent ; Curtis, Nigel ; Zimmermann, Petra

In: BMJ Open, 2020, vol. 10, no. 6, p. e036275

Introduction: There is compositional overlap between the maternal intestinal microbiome, the breast milk microbiome and the infant oral and intestinal microbiome. Antibiotics cause profound changes in the microbiome. However, the effect of intrapartum and early-life antibiotics on the maternal intestinal and breast milk microbiome, and the infant oral and intestinal microbiome, and whether...