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Comparison of phenotypic methods for the detection of penicillinase in Staphylococcus aureus and proposal of a practical diagnostic approach

Hombach, Michael ; Weissert, Christoph ; Senn, Maria Magdalena ; Zbinden, Reinhard

In: Journal of Antimicrobial Chemotherapy, 2017, vol. 72, no. 4, p. 1089-1093

Fully automated disc diffusion for rapid antibiotic susceptibility test results: a proof-of-principle study

Hombach, Michael

In: Journal of Antimicrobial Chemotherapy, ///-

Increased risk of joint failure in hip prostheses infected with Staphylococcus aureus treated with debridement, antibiotics and implant retention compared to Streptococcus

Betz, Michael ; Abrassart, Sophie ; Vaudaux, Pierre ; Gjika, Ergys ; Schindler, Maximilian ; Billières, Julien ; Zenelaj, Besa ; Suvà, Domizio ; Peter, Robin ; Uçkay, Ilker

In: International Orthopaedics, 2015, vol. 39, no. 3, p. 397-401

Rapid detection of ESBL, carbapenemases, MRSA and other important resistance phenotypes within 6-8 h by automated disc diffusion antibiotic susceptibility testing

Hombach, Michael

In: Journal of Antimicrobial Chemotherapy, ///-

Comparative Genomics of Community-Associated Methicillin-Resistant Staphylococcus aureus Shows the Emergence of Clone ST8-USA300 in Geneva, Switzerland

Von Dach, Elodie ; Diene, Seydina M. ; Fankhauser, Carolina ; Schrenzel, Jacques ; Harbarth, Stephan ; François, Patrice

In: The Journal of Infectious Diseases, 2016, vol. 213, no. 9, p. 1370-1379

Prospective, cross-sectional study on MSSA and MRSA colonisation in hospitalised children

Johnson, Kristen ; Frei, Reno ; Heininger, Ulrich

In: European Journal of Pediatrics, 2015, vol. 174, no. 9, p. 1255-1262

Detecting selection from linked sites using an f-model

Galimberti, Marco ; Leuenberger, Christoph ; Wolf, Beat ; Szilágyi, Sándor Miklós ; Foll, Matthieu ; Wegmann, Daniel

In: Genetics, 2020, vol. 216, no. 4, p. 1205–1215

Allele frequencies vary across populations and loci, even in the presence of migration. While most differences may be due to genetic drift, divergent selection will further increase differentiation at some loci. Identifying those is key in studying local adaptation, but remains statistically challenging. A particularly elegant way to describe allele frequency differences among populations...

NGS-based S. aureus typing and outbreak analysis in clinical microbiology laboratories : Lessons learned from a Swiss-wide proficiency test

Dylus, David ; Pillonel, Trestan ; Opota, Onya ; Wüthrich, Daniel ; Seth-Smith, Helena M. B. ; Egli, Adrian ; Leo, Stefano ; Lazarevic, Vladimir ; Schrenzel, Jacques ; Laurent, Sacha ; Bertelli, Claire ; Blanc, Dominique S. ; Neuenschwander, Stefan ; Ramette, Alban ; Falquet, Laurent ; Imkamp, Frank ; Keller, Peter M. ; Kahles, Andre ; Oberhaensli, Simone ; Barbié, Valérie ; Dessimoz, Christophe ; Greub, Gilbert ; Lebrand, Aitana

In: Frontiers in Microbiology, 2020, vol. 11, p. 591093

Whole genome sequencing (WGS) enables high resolution typing of bacteria up to the single nucleotide polymorphism (SNP) level. WGS is used in clinical microbiology laboratories for infection control, molecular surveillance and outbreak analyses. Given the large palette of WGS reagents and bioinformatics tools, the Swiss clinical bacteriology community decided to conduct a ring trial (RT) to...

High colonization rate and heterogeneity of ESBL- and carbapenemase-producing enterobacteriaceae isolated from gull feces in Lisbon, Portugal

Aires-de-Sousa, Marta ; Fournier, Claudine ; Lopes, Elizeth ; Lencastre, Hermínia de ; Nordmann, Patrice ; Poirel, Laurent

In: Microorganisms, 2020, vol. 8, no. 10, p. 1487

In order to evaluate whether seagulls living on the Lisbon coastline, Portugal, might be colonized and consequently represent potential spreaders of multidrug-resistant bacteria, a total of 88 gull fecal samples were screened for detection of extended- spectrum β-lactamase (ESBL)- or carbapenemase-producing Enterobacteriaceae for methicillin-resistant Staphylococcus aureus (MRSA) and for...

Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)

Sovari, Sara Nasiri ; Vojnovic, Sandra ; Bogojevic, Sanja Skaro ; Crochet, Aurélien ; Pavic, Aleksandar ; Nikodinovic-Runic, Jasmina ; Zobi, Fabio

In: European Journal of Medicinal Chemistry, 2020, vol. 205, p. 112533

We have prepared a series of ten 3-arylcoumarin molecules, their respective fac- [Re(CO)3(bpy)L]+ and fac-[Re(CO)3(L⁀L)Br] complexes and tested all compounds for their antimicrobial efficacy. Whereas the 3-arylcoumarin ligands are virtually inactive against the human-associated pathogens with minimum inhibitory concentrations (MICs) > 150 μM, when coordinated to the fac-[Re(CO)3]+ core,...