In: Non-coding RNA, 2021, vol. 7, no. 2, p. 13
Stressful conditions induce the cell to save energy and activate a rescue program modulated by mammalian target of rapamycin (mTOR). Along with transcriptional and translational regulation, the cell relies also on post-transcriptional modulation to quickly adapt the translation of essential proteins. MicroRNAs play an important role in the regulation of protein translation, and their...
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In: The Journal of Clinical Endocrinology & Metabolism, 2018, vol. 103, no. 9, p. 3466-3476
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In: Acta Neuropathologica, 2015, vol. 129, no. 5, p. 679-693
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In: Human Reproduction Update, 2016, vol. 22, no. 3, p. 382-403
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In: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie, ///-
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In: Journal of Molecular Medicine, 2015, vol. 93, no. 10, p. 1061-1073
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In: Der Pathologe, 2015, vol. 36, no. 3, p. 220-228
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In: Cardiovascular Research, 2016, vol. 109, no. 1, p. 103-114
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In: The Journal of Clinical Endocrinology & Metabolism, 2017, vol. 102, no. 5, p. 1712-1718
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In: Cancers, 2019, vol. 11, no. 6, p. 775
The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling cascade is an important therapeutic target for lymphomas. Rapamycin-derivates as allosteric mTOR complex 1 (TORC1) inhibitors have shown moderate preclinical and clinical anti-lymphoma activity. Here, we assessed the anti-tumor activity of PQR620, a novel brain penetrant dual TORC1/2 inhibitor, in 56...
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