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Targeting the DNA damage response for patients with lymphoma : preclinical and clinical evidences

Carrassa, Laura ; Colombo, Ilaria ; Damia, Giovanna ; Bertoni, Francesco

In: Cancer treatment reviews, 2020, vol. 90, p. 11

The DNA damage response (DDR) is a well-coordinated cellular network activated by DNA damage. The unravelling of the key players in DDR, their specific inactivation in different tumor types and the synthesis of specific chemical inhibitors of DDR represent a new hot topic in cancer therapy. In this article, we will review the importance of DDR in lymphoma development and how this can be...

Dietary chloride deficiency syndrome : pathophysiology, history, and systematic literature review

Signorelli, Giulia C. ; Bianchetti, Mario G. ; Jermini, Luca M. M. ; Agostoni, Carlo ; Milani, Gregorio P. ; Simonetti, Giacomo D. ; Lava, Sebastiano A. G.

In: Nutrients, 2020, vol. 12, no. 11, p. 10 p

Metabolic alkalosis may develop as a consequence of urinary chloride (and sodium) wasting, excessive loss of salt in the sweat, or intestinal chloride wasting, among other causes. There is also a likely underrecognized association between poor salt intake and the mentioned electrolyte and acid–base abnormality. In patients with excessive loss of salt in the sweat or poor salt intake, the...

Changes in autopsy rates among cancer patients and their impact on cancer statistics from a public health point of view: a longitudinal study from 1980 to 2010 with data from Cancer Registry Zurich

Bieri, Uwe ; Moch, Holger ; Dehler, Silvia ; Korol, Dimitri ; Rohrmann, Sabine

In: Virchows Archiv, 2015, vol. 466, no. 6, p. 637-643

Dietary potassium and the renal control of salt balance and blood pressure

Penton, David

In: Pflügers Archiv : European Journal of Physiology, ///-

Associations between objective and self-reported physical activity and vitamin D serum levels in the US population

Wanner, Miriam ; Richard, Aline ; Martin, Brian ; Linseisen, Jakob ; Rohrmann, Sabine

In: Cancer Causes & Control, 2015, vol. 26, no. 6, p. 881-891

Sodium intake and blood pressure in children and adolescents: a systematic review and meta-analysis of experimental and observational studies

Leyvraz, Magali ; Chatelan, Angeline ; da Costa, Bruno R. ; Taffé, Patrick ; Paradis, Gilles ; Bovet, Pascal ; Bochud, Murielle ; Chiolero, Arnaud

In: International Journal of Epidemiology, 2018, vol. 47, no. 6, p. 1796-1810

Pregnancy loss of control over eating: a longitudinal study of maternal and child outcomes

Micali, Nadia ; Al Essimii, Haya ; Field, Alison E. ; Treasure, Janet

In: The American Journal of Clinical Nutrition, 2018, vol. 108, no. 1, p. 101-107

Twenty-year trends in dietary patterns in French-speaking Switzerland: toward healthier eating

Marques-Vidal, Pedro ; Gaspoz, Jean-Michel ; Theler, Jean-Marc ; Guessous, Idris

In: The American Journal of Clinical Nutrition, 2017, vol. 106, no. 1, p. 217-224

Classification of Intraoperative Complications: Reply

Dell-Kuster, Salome ; Clavien, Pierre-Alain ; Bucher, Heiner ; Rosenthal, Rachel

In: World Journal of Surgery, 2015, vol. 39, no. 12, p. 3033-3034

Retinoic acid sensitivity of triple-negative breast cancer cells characterized by constitutive activation of the NOTCH1 pathway : the role of RARβ

Paroni, Gabriela ; Zanetti, Adriana ; Barzago, Maria Monica ; Kurosaki, Mami ; Guarrera, Luca ; Fratelli, Maddalena ; Troiani, Martina ; Ubezio, Paolo ; Bolis, Marco ; Vallerga, Arianna ; Biancardi, Federica ; Terao, Mineko ; Garattini, Enrico

In: Cancers, 2020, vol. 12, no. 10, p. 23 p

Triple-negative breast cancer (TNBC) is a heterogeneous disease that lacks effective therapeutic options. In this study, we profile eighteen TNBC cell lines for their sensitivity to the anti-proliferative action of all-trans retinoic acid (ATRA). The only three cell lines (HCC-1599, MB- 157 and MDA-MB-157) endowed with ATRA-sensitivity are characterized by genetic aberrations of the NOTCH1-gene,...