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Université de Fribourg

Effects of anti-PD-1 immunotherapy on tumor regression: insights from a patient-derived xenograft model

Martín-Ruiz, Asunción ; Fiuza-Luces, Carmen ; Martínez-Martínez, Esther ; Arias, Clemente F. ; Gutiérrez, Lourdes ; Ramírez, Manuel ; Martín-Acosta, Paloma ; Coronado, Maria José ; Lucia, Alejandro ; Provencio, Mariano

In: Scientific Reports, 2020, vol. 10, no. 1, p. 7078

Immunotherapies, such as checkpoint blockade of programmed cell death protein-1 (PD-1), have resulted in unprecedented improvements in survival for patients with lung cancer. Nonetheless, not all patients benefit equally and many issues remain unresolved, including the mechanisms of action and the possible effector function of immune cells from non-lymphoid lineages. The purpose of this...

Università della Svizzera italiana

Long non-coding RNAs as molecular signatures for canine B-Cell lymphoma characterization

Cascione, Luciano ; Giudice, Luca ; Ferraresso, Serena ; Marconato, Laura ; Giannuzzi, Diana ; Napoli, Sara ; Bertoni, Francesco ; Giugno, Rosalba ; Aresu, Luca

In: Non-coding RNA, 2019, vol. 5, no. 3, p. 47

Diffuse large B-cell lymphoma (DLBCL), marginal zone lymphoma (MZL) and follicular lymphoma (FL) are the most common B-cell lymphomas (BCL) in dogs. Recent investigations have demonstrated overlaps of these histotypes with the human counterparts, including clinical presentation, biologic behavior, tumor genetics, and treatment response. The molecular mechanisms that underlie canine BCL are...

Università della Svizzera italiana

Is there a role for dual PI3K/mTOR inhibitors for patients affected with lymphoma?

Tarantelli, Chiara ; Lupia, Antonio ; Stathis, Anastasios ; Bertoni, Francesco

In: International journal of molecular sciences, 2020, vol. 21, no. 3, p. 21 p

The activation of the PI3K/AKT/mTOR pathway is a main driver of cell growth, proliferation, survival, and chemoresistance of cancer cells, and, for this reason, represents an attractive target for developing targeted anti- cancer drugs. There are plenty of preclinical data sustaining the anti-tumor activity of dual PI3K/mTOR inhibitors as single agents and in combination in lymphomas. Clinical...

Consortium of Swiss Academic Libraries

Treatment of Primary CNS Lymphoma

Roth, Patrick ; Stupp, Roger ; Eisele, Günter ; Weller, Michael

In: Current Treatment Options in Neurology, 2014, vol. 16, no. 1, p. 1-14

Consortium of Swiss Academic Libraries

Auger radiation targeted into DNA: a therapy perspective

Buchegger, Franz ; Perillo-Adamer, Florence ; Dupertuis, Yves ; Bischof Delaloye, Angelika

In: European Journal of Nuclear Medicine and Molecular Imaging, 2006, vol. 33, no. 11, p. 1352-1363