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Université de Fribourg

TGFBI modulates tumour hypoxia and promotes breast cancer metastasis

Fico, Flavia ; Santamaria‐Martínez, Albert

In: Molecular Oncology, 2020, vol. 14, no. 12, p. 3198–3210

Breast cancer metastasis is a complex process that depends not only on intrinsic characteristics of metastatic stem cells, but also on the particular microenvironment that supports their growth and modulates the plasticity of the system. In search for microenvironmental factors supporting cancer stem cell (CSC) growth and tumour progression to metastasis, we here investigated the role of the...

Université de Fribourg

CD47 promotes age-associated deterioration in angiogenesis, blood flow and glucose homeostasis

Ghimire, Kedar ; Li, Yao ; Chiba, Takuto ; Julovi, Sohel M. ; Li, Jennifer ; Ross, Mark A. ; Straub, Adam C. ; O’Connell, Philip J. ; Rüegg, Curzio ; Pagano, Patrick J. ; Isenberg, Jeffrey S. ; Rogers, Natasha M.

In: Cells, 2020, vol. 9, no. 7, p. 1695

The aged population is currently at its highest level in human history and is expected to increase further in the coming years. In humans, aging is accompanied by impaired angiogenesis, diminished blood flow and altered metabolism, among others. A cellular mechanism that impinges upon these manifestations of aging can be a suitable target for therapeutic intervention. Here we identify cell...

Consortium of Swiss Academic Libraries

Aldehyde dehydrogenase in tobacco pollen

op den Camp, Roel ; Kuhlemeier*, Cris

In: Plant Molecular Biology, 1997, vol. 35, no. 3, p. 355-365