In: Brain, 2016, vol. 139, no. 1, p. 39-46
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In: Neurochemical Research, 2015, vol. 40, no. 12, p. 2639-2646
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In: Journal of Neurology, 2015, vol. 262, no. 4, p. 870-880
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In: Neurology Research International, 2019, vol. 2019, p. 1–5
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with involvement of the upper and lower motor neurons. Since the loss of fine motor skills is one of the earliest signs of ALS, the hypothesis was tested if the nine hole PEG test (NHPT) and transcranial magnet stimulation (TMS) with resting-motor threshold (RMT) could be useful in monitoring disease progression. Methods. We...
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In: Ageing Research Reviews, 2019, vol. 55, p. 100956
Sensory capacities like smell, taste, hearing, vision decline with aging, but increasing evidence show that sensory dysfunctions are one of the early signs diagnosing the conversion from physiological to pathological brain state. Smell loss represents the best characterized sense in clinical practice and is considered as one of the first preclinical signs of Alzheimer’s and Parkinson’s...
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In: Plos pathogens, 2018, vol. 14, no. 10, p. e1007335
Antibodies to the prion protein, PrP, represent a promising therapeutic approach against prion diseases but the neurotoxicity of certain anti-PrP antibodies has caused concern. Here we describe scPOM-bi, a bispecific antibody designed to function as a molecular prion tweezer. scPOM-bi combines the complementarity-determining regions of the neurotoxic antibody POM1 and the neuroprotective...
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In: Journal of Neurology, 2014, vol. 261, no. 10, p. 1894-1901
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In: Journal of Neurology, 2014, vol. 261, no. 4, p. 732-737
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In: Acta Neuropathologica, 2012, vol. 124, no. 5, p. 705-716
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In: Sozial- und Präventivmedizin, 2006, vol. 51, no. 4, p. 210-220
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