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Gut Microbial Transformation of the Dietary Imidazoquinoxaline Mutagen MelQx Reduces Its Cytotoxic and Mutagenic Potency

Zhang, Jianbo ; Empl, Michael T. ; Schwab, Clarissa ; Fekry, Mostafa I. ; Engels, Christina ; Schneider, Mirjam ; Lacroix, Christophe ; Steinberg, Pablo ; Sturla, Shana J.

In: Toxicological Sciences, 2017, vol. 159, no. 1, p. 266-276

Draft genome sequences of multidrug-resistant acinetobacter sp. strains from colombian hospitals

Barreto-Hernández, Emiliano ; Falquet, Laurent ; Reguero, María T. ; Mantilla, José R. ; Valenzuela, Emilia M. ; González, Elsa ; Cepeda, Alexandra ; Escalante, Andrea

In: Genome Announcements, 2013, vol. 1, no. 6, p. -

The draft genome sequences of the strains Acinetobacter baumannii 107m, Acinetobacter nosocomialis 28F, and Acinetobacter pittii 42F, isolated from Colombian hospitals, are reported here. These isolates are causative of nosocomial infections and are classified as multidrug resistant, as they showed resistance to four different antibiotic groups.

Draft genome sequence of a blaNDM-1- and blaOXA-244-carrying multidrug-resistant Escherichia coli D-ST69 clinical isolate from Egypt

Soliman, Ahmed M. ; Ramadan, Hazem ; Sadek, Mustafa ; Nariya, Hirofumi ; Shimamoto, Toshi ; Hiott, Lari M. ; Frye, Jonathan G. ; Jackson, Charlene R. ; Shimamoto, Tadashi

In: Journal of Global Antimicrobial Resistance, 2020, vol. 22, p. 832–834

Objectives: This study describes the first draft genome sequence of a multidrug- resistant (MDR) Escherichia coli D-ST69 clinical isolate from Egypt carrying blaNDM-1 and blaOXA-244.Methods: The strain was isolated in December 2014 from a wound pus swab of a male patient in the city of Kafr El-Sheikh using MacConkey agar containing 2 μg/mL meropenem. The strain was subjected to antimicrobial ...

Granzyme B attenuates bacterial virulence by targeting secreted factors

López León, Diego ; Matthey, Patricia ; Fellay, Isabelle ; Blanchard, Marianne ; Martinvalet, Denis ; Mantel, Pierre-Yves ; Filgueira, Luis ; Walch, Michael

In: iScience, 2020, vol. 23, no. 3, p. 100932

Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to contribute crucially to antibacterial defense. Here we show that granzyme B degrades multiple secreted virulence mediators from Listeria monocytogenes,...

Draft genome sequence of an mcr-1/IncI2-carrying multidrug-resistant Escherichia coli B1:ST101 isolated from meat and meat products in Egypt

Sadek, Mustafa ; Poirel, Laurent ; Nordmann, Patrice ; Nariy, Hirofumi ; Shimamoto, Toshi ; Shimamoto, Tadashi

In: Journal of Global Antimicrobial Resistance, 2020, vol. 20, p. 41–42

Large-scale comparison of toxin and antitoxins in Listeria monocytogenes

Agüero, José Antonio ; Akarsu, Hatice ; Aguilar-Bultet, Lisandra ; Oevermann, Anna ; Falquet, Laurent

In: Toxins, 2020, vol. 12, no. 1, p. 29

Toxin–antitoxin systems (TASs) are widely distributed in prokaryotes and encode pairs of genes involved in many bacterial biological processes and mechanisms, including pathogenesis. The TASs have not been extensively studied in Listeria monocytogenes (Lm), a pathogenic bacterium of the Firmicutes phylum causing infections in animals and humans. Using our recently published TASmania...

How the interaction of Listeria monocytogenes and Acanthamoeba spp. affects growth and distribution of the food borne pathogen

Schuppler, Markus

In: Applied Microbiology and Biotechnology, 2014, vol. 98, no. 7, p. 2907-2916

Acanthamoeba release compounds which promote growth of Listeria monocytogenes and other bacteria

Fieseler, Lars ; Doyscher, Dominik ; Loessner, Martin ; Schuppler, Markus

In: Applied Microbiology and Biotechnology, 2014, vol. 98, no. 7, p. 3091-3097

Stability of the Maternal Gut Microbiota During Late Pregnancy and Early Lactation

Jost, Ted ; Lacroix, Christophe ; Braegger, Christian ; Chassard, Christophe

In: Current Microbiology, 2014, vol. 68, no. 4, p. 419-427

Diarrheagenic enteroaggregative Escherichia coli causing urinary tract infection and bacteremia leading to sepsis

Herzog, K. ; Engeler Dusel, J. ; Hugentobler, M. ; Beutin, L. ; Sägesser, G. ; Stephan, R. ; Hächler, H. ; Nüesch-Inderbinen, M.

In: Infection, 2014, vol. 42, no. 2, p. 441-444