In: Cancer Immunology, Immunotherapy, 2015, vol. 64, no. 5, p. 635-644
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In: Toxicological Sciences, 2017, vol. 157, no. 1, p. 112-128
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In: ACS Omega, 2020, vol. 5, no. 38, p. 24724–24732
Cellular delivery of DNA vectors for the expression of therapeutic proteins is a promising approach to treat monogenic disorders or cancer. Significant efforts in a preclinical and clinical setting have been made to develop potent nonviral gene delivery systems based on lipoplexes composed of permanently cationic lipids. However, transfection efficiency and tolerability of such systems are in...
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In: ACS Sensors, 2020, vol. 5, no. 8, p. 2338–2343
Reactions templated by nucleic acids are currently at the heart of applications in biosensing and drug release. The number of chemical reactions selectively occurring only in the presence of the template, in aqueous solutions, and at room temperature and able to release a chemical moiety is still very limited. Here, we report the use of the p-nitrophenyl carbonate (NPC) as a new reactive...
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In: Molecules, 2020, vol. 25, no. 7, p. 22 p
The early and late development of new anticancer drugs, small molecules or peptides can be slowed down by some issues such as poor selectivity for the target or poor ADME properties. Computer-aided drug design (CADD) and target drug delivery (TDD) techniques, although apparently far from each other, are two research fields that can give a significant contribution to overcome these problems....
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In: Gels, 2020, vol. 6, no. 1, p. 6
Drug delivery is a fascinating research field with several development opportunities. Great attention is now focused on colloidal systems, nanoparticles, and nanogels and on the possibility of modifying them in order to obtain precise targeted drug delivery systems. The aim of this review is to give an overview of the main available surface functionalization and coating strategies that can be...
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In: Cancer Immunology, Immunotherapy, 2014, vol. 63, no. 9, p. 901-910
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In: Pharmaceutical Research, 2014, vol. 31, no. 5, p. 1099-1105
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In: European Journal of Clinical Pharmacology, 2014, vol. 70, no. 1, p. 1-11
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In: Angiogenesis, 2014, vol. 17, no. 2, p. 359-371
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