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Université de Fribourg

HSP90 and co-chaperones: a multitaskers’ view on plant hormone biology

Donato, Martin di ; Geisler, Markus

In: FEBS Letters, 2019, vol. 593, no. 13, p. 1415–1430

In order to survive under ever‐changing conditions plants must be able to adaptively respond to their environment. Plant hormones and the signaling cross‐talk among them play a key role in integrating external and internal cues, enabling the plants to acclimate accordingly. HSP90 and several of its co‐chaperones are known as pleiotropic factors involved in the signaling pathways of...

Università della Svizzera italiana

Structural biology of STAT3 and its implications for anticancer therapies development

Sgrignani, Jacopo ; Garofalo, Maura ; Matkovic, Milos ; Merulla, Jessica ; Catapano, Carlo V. ; Cavalli, Andrea

In: International journal of molecular sciences, 2018, vol. 19, no. 6, p. 1591

Transcription factors are proteins able to bind DNA and induce the transcription of specific genes. Consequently, they play a pivotal role in multiple cellular pathways and are frequently over-expressed or dysregulated in cancer. Here, we will focus on a specific “signal transducer and activator of transcription” (STAT3) factor that is involved in several pathologies, including cancer....

Université de Fribourg

Incidence and developmental timing of endosperm failure in post-zygotic isolation between wild tomato lineages

Roth, Morgane ; Florez-Rueda, Ana M. ; Griesser, Stephan ; Paris, Margot ; Städler, Thomas

In: Annals of Botany, 2018, vol. 121, no. 1, p. 107–118

Background and AimsDefective hybrid seed development in angiosperms might mediate the rapid establishment of intrinsic post-zygotic isolation between closely related species. Extensive crosses within and among three lineages of wild tomatoes (Solanum section Lycopersicon) were performed to address the incidence, developmental timing and histological manifestations of hybrid seed failure....

Université de Fribourg

Preliminary observations on the bone histology of the Middle Triassic pseudosuchian archosaur Batrachotomus kupferzellensis reveal fast growth with laminar fibrolamellar bone tissue

Klein, Nicole ; Foth, Christian ; Schoch, Rainer R.

In: Journal of Vertebrate Paleontology, 2017, vol. 37, no. 4, p. e1333121

The bone tissue of femur, rib, and gastralia from three different individuals of the Middle Triassic pseudosuchian Batrachotomus kupferzellensis from southern Germany is studied. The femoral bone tissue comprises laminar fibrolamellar bone tissue throughout and is stratified by three annual growth cycles, indicating that the individual died early in its fourth year of life, at which time it...

Consortium of Swiss Academic Libraries

Yeasts as models in cell biology

Martin, Sophie G.

In: FEMS Microbiology Reviews, 2014, vol. 38, no. 2, p. 143-143