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Université de Fribourg

Epithelial sodium channel-mediated sodium transport is not dependent on the membrane-bound serine protease CAP2/Tmprss4

Keppner, Anna ; Andreasen, Ditte ; Mérillat, Anne-Marie ; Bapst, Julie ; Ansermet, Camille ; Wang, Qing ; Maillard, Marc ; Malsure, Sumedha ; Nobile, Antoine ; Hummler, Edith

In: PLoS ONE, 2015, vol. 10, no. 8, p. e0135224

The membrane-bound serine protease CAP2/Tmprss4 has been previously identified in vitro as a positive regulator of the epithelial sodium channel (ENaC). To study its in vivo implication in ENaC-mediated sodium absorption, we generated a knockout mouse model for CAP2/Tmprss4. Mice deficient in CAP2/Tmprss4 were viable, fertile, and did not show any obvious histological abnormalities. Unexpectedly,...