Université de Fribourg

Rheological characterization of nanostructured material based on Polystyrene-b-poly(ethylene-butylene)-b-polystyrene (SEBS) block copolymer: Effect of block copolymer composition and nanoparticle geometry

Hasanabadi, Noushin ; Nazockdast, Hossein ; Balog, Sandor ; Lattuada, Marco

In: Composites Science and Technology, 2017, vol. 149, no. Supplement C, p. 192–206

Block copolymer (BCP) nanocomposite systems are of broad interest; however, reports on the role of nanoparticles on microphase separation behavior are rare. The goal of present study is to investigate the preparation of composite nanostructured materials containing Multi-Walled Carbon Nanotubes (MWCNTs) or graphene nanoplates. BCP nanocomposites based on the linear triblock copolymer, ...

Université de Fribourg

Removal of cells from body fluids by magnetic separation in batch and continuous mode: influence of bead size, concentration, and contact time

Bohmer, Nils ; Demarmels, Nino ; Tsolaki, Elena ; Gerken, Lukas ; Keevend, Kerda ; Bertazzo, Sergio ; Lattuada, Marco ; Herrmann, Inge K.

In: ACS Applied Materials & Interfaces, 2017, vol. 9, no. 35, p. 29571–29579

The magnetic separation of pathogenic compounds from body fluids is an appealing therapeutic concept. Recently, removal of a diverse array of pathogens has been demonstrated using extracorporeal dialysis-type devices. The contact time between the fluid and the magnetic beads in such devices is limited to a few minutes. This poses challenges, particularly if large compounds such as bacteria or...

Université de Fribourg

Reinterpretation of the mechanical reinforcement of polymer nanocomposites reinforced with cellulose nanorods

Sapkota, Janak ; Garcia, Julio Cesar Martinez ; Lattuada, Marco

In: Journal of Applied Polymer Science, 2017, vol. 134, no. 35, p. -

The mechanical reinforcement of nanocomposites containing nanorods-like fillers such as cellulose nanocrystals (CNCs) isoften interpreted by adapting the classical parallel–series model, assuming a simple hyperbolic dependence between the percolationthreshold and aspect ratio. However, such assumptions are valid only for nanorods with high aspect ratio and often are misinterpretingthe...

Université de Fribourg

Modeling of the degradation of poly(ethylene glycol)-co-(lactic acid)-dimethacrylate hydrogels

Diederich, Vincent E. G. ; Villiger, Thomas ; Storti, Giuseppe ; Lattuada, Marco

In: Macromolecules, 2017, vol. 50, no. 14, p. 5527–5538

Because of their similarity with extracellular matrix, hydrogels are ideal substrates for cell growth. Hydrogels made of synthetic polymers are excellent alternatives to natural ones and offer the key advantage of precisely controllable degradation times. In this work, hydrogels have been prepared from modified poly(ethylene glycol) macromonomers, functionalized on both ends first with a few...

Université de Fribourg

Cellular shuttles: monocytes/macrophages exhibit transendothelial transport of nanoparticles under physiological flow

Moore, Thomas L. ; Hauser, Daniel ; Gruber, Thomas ; Rothen-Rutishauser, Barbara ; Lattuada, Marco ; Petri-Fink, Alke ; Lyck, Ruth

In: ACS Applied Materials & Interfaces, 2017, vol. 9, no. 22, p. 18501–18511

A major hurdle in the development of biomedical nanoparticles (NP) is understanding how they interact with complex biological systems and navigate biological barriers to arrive at pathological targets. It is becoming increasingly evident that merely controlling particle physicochemical properties may not be sufficient to mediate particle biodistribution in dynamic environments. Thus,...

Université de Fribourg

Growth and aggregation regulate clusters structural properties and gel time

Lazzari, Stefano ; Lattuada, Marco

In: The Journal of Physical Chemistry B, 2017, vol. 121, no. 11, p. 2511–2524

Silica aerogels’ unique physical and chemical properties make them fascinating materials for a wide variety of applications. In addition to hydrophobization by silylation, aging is very important in the synthesis of silica aerogel by ambient pressure drying. Here we systematically study the effect of aging on the physico-chemical properties of silica aerogel with emphasis on ambient dried...

Université de Fribourg

Effect of aging on silica aerogel properties

Iswar, Subramaniam ; Malfait, Wim J. ; Balog, , Sandor ; Winnefeld, Frank ; Lattuada, Marco ; Koebel, Matthias M.

In: Microporous and Mesoporous Materials, 2017, vol. 241, p. 293–302

Silica aerogels’ unique physical and chemical properties make them fascinating materials for a wide variety of applications. In addition to hydrophobization by silylation, aging is very important in the synthesis of silica aerogel by ambient pressure drying. Here we systematically study the effect of aging on the physico-chemical properties of silica aerogel with emphasis on ambient dried...

Université de Fribourg

Theranostic body fluid cleansing: rationally designed magnetic particles enable capturing and detection of bacterial pathogens

Lattuada, Marco ; Ren, Q. ; Zuber, F. ; Galli, M. ; Bohmer, N. ; Matter, M. T. ; Wichser, A. ; Bertazzo, S. ; Pier, G. B. ; Herrmann, I. K.

In: Journal of Materials Chemistry B, 2016, vol. 4, no. 44, p. 7080–7086

We report on theoretical and experimental considerations on bacteria capturing and enrichment via magnetic separation enabling integrated diagnosis and treatment of blood stream infections. We show optimization of carrier-pathogen interactions based on a mathematical model followed by an experimental proof-of-concept study along with investigations on the process safety.

Université de Fribourg

A lock-in-based method to examine the thermal signatures of magnetic nanoparticles in the liquid, solid and aggregated states

Monnier, Christophe A. ; Lattuada, Marco ; Burnand, David ; Crippa, F. ; Martinez-Garcia, J. C. ; Hirt, A. M. ; Rothen-Rutishauser, B. ; Bonmarin, M. ; Petri-Fink, Alke

In: Nanoscale, 2016, vol. 8, no. 27, p. 13321–13332

We propose a new methodology based on lock-in thermography to study and quantify the heating power of magnetic nanoparticles. Superparamagnetic iron oxide nanoparticles exposed to a modulated alternating magnetic field were used as model materials to demonstrate the potency of the system. Both quantitative and qualitative information on their respective heating power was extracted at high...