Université de Fribourg

SV40-induced expression of calretinin protects mesothelial cells from asbestos cytotoxicity and may be a key factor contributing to mesothelioma pathogenesis

Henzi, Thomas ; Blum, Walter-Vincent ; Pfefferli, Martine ; Kawecki, Tadeusz J. ; Salicio, Valérie ; Schwaller, Beat

In: American Journal of Pathology, 2009, vol. 174, p. 2324-2336

The calcium-binding protein calretinin has emerged as a useful marker for the identification of mesotheliomas of the epithelioid and mixed types, but its putative role in tumor development has not been addressed previously. Although exposure to asbestos fibers is considered the main cause of mesothelioma, undoubtedly, not all mesothelioma patients have a history of asbestos exposure. The question...

Université de Fribourg

Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures

Schwaller, Beat ; Tetko, I. V. ; Tandon, P. ; Silveira, D. C. ; Vreugdenhil, M. ; Henzi, Thomas ; Potier, M. -C. ; Celio, Marco R. ; Villa, A. E. P.

In: Molecular and Cellular Neuroscience, 2004, vol. 25, no. 4, p. 650-663

Networks of GABAergic interneurons are of utmost importance in generating and promoting synchronous activity and are involved in producing coherent oscillations. These neurons are characterized by their fast-spiking rate and by the expression of the Ca2+-binding protein parvalbumin (PV). Alteration of their inhibitory activity has been proposed as a major mechanism leading to epileptic seizures...