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The role of tissue-type plasminogen activator system in amphetamine-induced conditional place preference extinction and reinstatement

Bahi, Amine ; Kusnecov, Alexander ; Dreyer, Jean-Luc

In: Neuropsychopharmacology, 2008, vol. 33, p. 2726–2734

Extracellular serine proteases of the plasminogen activator family (tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) may modulate synaptic adhesion and associate with learning behavior. Psychostimulants strongly induce their expression in the mesolimbic dopaminergic pathway, but cocaine preferentially induces uPA, whereas morphine and amphetamine...