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Université de Fribourg

Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion

Estermann, Manuela ; Huang, Yen-Lin ; Septiadi, Dedy ; Ritz, Danilo ; Liang, Ching-Yeu ; Jacob, Francis ; Drasler, Barbara ; Petri-Fink, Alke ; Heinzelmann-Schwarz, Viola ; Rothen-Rutishauser, Barbara

In: PLOS ONE, 2020, vol. 15, no. 12, p. e0241500

The presence of ascites in the peritoneal cavity leads to morphological and functional changes of the peritoneal mesothelial cell layer. Cells loose cell-cell interactions, rearrange their cytoskeleton, activate the production of fibronectin, and change their cell surface morphology in a proinflammatory environment. Moreover, ovarian cancer cell adhesion has been shown to be facilitated by...