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Population genetics of duplicated alternatively spliced exons of the Dscam gene in Daphnia and Drosophila

Brites, Daniela ; Encinas-Viso, Francisco ; Ebert, Dieter ; Pasquier, Louis Du ; Haag, Christoph R.

In: PLoS ONE, 2011, vol. 6, no. 12, p. e27947

In insects and crustaceans, the Down syndrome cell adhesion molecule (Dscam) occurs in many different isoforms. These are produced by mutually exclusive alternative splicing of dozens of tandem duplicated exons coding for parts or whole immunoglobulin (Ig) domains of the Dscam protein. This diversity plays a role in the development of the nervous system and also in the immune system. Structural...