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Université de Fribourg

Increased impulsive behavior and risk proneness following lentivirus-mediated dopamine transporter over-expression in rats' nucleus accumbens

Adriani, W. ; Boyer, Frederic ; Gioiosa, L. ; Macrì, S. ; Dreyer, Jean-Luc ; Laviola, G.

In: Neuroscience, 2009, vol. 159, no. 1, p. 47-58

Multiple theories have been proposed for sensation seeking and vulnerability to impulse-control disorders [Zuckerman M, Kuhlman DM (2000) Personality and risk-taking: Common biosocial factors. J Pers 68:999–1029], and many of these rely on a dopamine system deficit. Available animal models reproduce only some behavioral symptoms and seem devoid of construct validity. We used lentivirus tools...