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De novo expression of parvalbumin in ependymal cells in response to brain injury promotes ependymal remodeling and wound repair

Szabolcsi, Viktória ; Celio, Marco R.

In: Glia, 2014, p. -

The calcium-binding protein parvalbumin (PV) hallmarks subpopulations of interneurons in the murine brain. We serendipitously observed the de novo expression of PV in ependymal cells of the lateral ventricle wall following in vivo lesioning and brain slicing for the preparation of organotypic hippocampal slice cultures (OHSCs). In OHSCs, de novo PV-expression begins shortly after the onset of...

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The role of parvalbumin and calbindin D28k in experimental scrapie

Voigtländer, T. ; Unterberger, U. ; Guentchev, M. ; Schwaller, Beat ; Celio, Marco R. ; Meyer, M. ; Budka, H.

In: Neuropathology and Applied Neurobiology, 2008, vol. 34, no. 4, p. 435 - 445

Aims: Prion diseases are generally characterized by pronounced neuronal loss. In particular, a subpopulation of inhibitory neurones, characterized by the expression of the calcium-binding protein parvalbumin (PV), is selectively destroyed early in the course of human and experimental prion diseases. By contrast, nerve cells expressing calbindin D28k (CB), another calcium-binding protein, as well...

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