Refine my results

Document type


Specific Collection


Università della Svizzera italiana

New shape control tools for rational Bézier curve design

Ramanantoanina, Andriamahenina ; Hormann, Kai

In: Computer aided geometric design, 2021, vol. 88, p. 11

Bézier curves are indispensable for geometric modelling and computer graphics. They have numerous favourable properties and provide the user with intuitive tools for editing the shape of a parametric polynomial curve. Even more control and flexibility can be achieved by associating a shape parameter with each control point and considering rational Bézier curves, which comes with the...

Università della Svizzera italiana

Crossover or non-crossover outcomes : tailored processing of homologous recombination intermediates

Sanchez, Aurore ; Reginato, Giordano ; Cejka, Petr

In: Current opinion in genetics & development, 2021, vol. 71, p. 39-47

DNA breaks may arise accidentally in vegetative cells or in a programmed manner in meiosis. The usage of a DNA template makes homologous recombination potentially error-free, however, recombination is not always accurate. Cells possess a remarkable capacity to tailor processing of recombination intermediates to fulfill a particular need. Vegetatively growing cells aim to maintain genome...

Università della Svizzera italiana

A refined propensity account for GRW theory

Lorenzetti, Lorenzo

In: Foundations of Physics, 2021, vol. 51, no. 2, p. 20

Spontaneous collapse theories of quantum mechanics turn the usual Schrödinger equation into a stochastic dynamical law. In particular, in this paper I will focus on the GRW theory. Two philosophical issues that can be raised about GRW concern (a) the ontology of the theory, in particular the nature of the wave function and its role within the theory, and (b) the interpretation of the objective...

Università della Svizzera italiana

Exon–Intron differential analysis reveals the role of competing endogenous RNAs in post-transcriptional regulation of translation

Munz, Nicolas ; Cascione, Luciano ; Parmigiani, Luca ; Tarantelli, Chiara ; Rinaldi, Andrea ; Cmiljanovic, Natasa ; Cmiljanovic, Vladimir ; Giugno, Rosalba ; Bertoni, Francesco ; Napoli, Sara

In: Non-coding RNA, 2021, vol. 7, no. 2, p. 13

Stressful conditions induce the cell to save energy and activate a rescue program modulated by mammalian target of rapamycin (mTOR). Along with transcriptional and translational regulation, the cell relies also on post-transcriptional modulation to quickly adapt the translation of essential proteins. MicroRNAs play an important role in the regulation of protein translation, and their...

Università della Svizzera italiana

A fast direct solver for nonlocal operators in wavelet coordinates

Harbrecht, Helmut ; Multerer, Michael

In: Journal of computational physics, 2021, vol. 428, p. 15 p

In this article, we consider fast direct solvers for nonlocal operators. The pivotal idea is to combine a wavelet representation of the system matrix, yielding a quasi- sparse matrix, with the nested dissection ordering scheme. The latter drastically reduces the fill-in during the factorization of the system matrix by means of a Cholesky decomposition or an LU decomposition, respectively. This...

Consortium of Swiss Academic Libraries

Robust Bayesian model averaging for the analysis of presence-absence data

Corani, Giorgio ; Mignatti, Andrea

In: Environmental and Ecological Statistics, 2015, vol. 22, no. 3, p. 513-534

Università della Svizzera italiana

Thioredoxin-related transmembrane proteins : TMX1 and little brothers TMX2, TMX3, TMX4 and TMX5

Guerra, Concetta ; Molinari, Maurizio

In: Cells, 2020, vol. 9, no. 9, p. 11 p

The endoplasmic reticulum (ER) is site of synthesis and maturation of membrane and secretory proteins in eukaryotic cells. The ER contains more than 20 members of the Protein Disulfide Isomerase (PDI) family. These enzymes regulate formation, isomerization and disassembly of covalent bonds between cysteine residues. As such, PDIs ensure protein folding, which is required to attain functional...

Università della Svizzera italiana

The MRE11 complex : a versatile toolkit for the repair of broken DNA

Reginato, Giordano ; Cejka, Petr

In: DNA repair, 2020, vol. 91–92, no. July–August, p. 13 p

When DNA breaks, the ends need to be stabilized and processed to facilitate subsequent repair, which can occur by either direct but error-prone end-joining with another broken DNA molecule or a more accurate homology-directed repair by the recombination machinery. At the same time, the presence of broken DNA triggers a signaling cascade that regulates the repair events and cellular progression...