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Università della Svizzera italiana

Approximation algorithms for survivable network design

Jabal Ameli, Afrouz ; Grandoni, Fabrizio (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2021 ; 2021INFO005.

Many relevant discrete optimization problems are believed to be hard to solve efficiently (i.e. they cannot be solved in polynomial time unless P=NP). An approximation algorithm is one of the ways to tackle these hard optimization problems. These algorithms have polynomial running time and compute a feasible solution whose value is within a proven factor (approximation factor) of the optimal...

Università della Svizzera italiana

Vitamin D status among male late adolescents living in southern Switzerland : role of body composition and lifestyle

Rabufetti, Andrea ; Milani, Gregorio P. ; Lava, Sebastiano A. G. ; Edefonti, Valeria ; Bianchetti, Mario G. ; Stettbacher, Andreas ; Muggli, Franco ; Simonetti, Giacomo

In: Nutrients, 2019, vol. 11, no. 11, p. 2727

Background: Poor vitamin D status is a worldwide health problem. Yet, knowledge about vitamin D status among adolescents in Southern Europe is limited. This study investigated concentrations and modulating factors of vitamin D in a healthy population of male late adolescents living in Southern Switzerland. Methods: All apparently healthy subjects attending for the medical evaluation before the...

Università della Svizzera italiana

From facet-based to visualised digital library interfaces : an empirical study of user experiences with digital libraries

Barifah, Maram Hassan ; Crestani, Fabio (Dir.) ; Landoni, Monica (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2021 ; 2021INFO004.

Digital library (DL) systems in the last decade have provided an unprecedented access to library content that were confined to their physical spaces. The last twenty years of the DL system renovation have witnessed several generations of online catalogs from the Online Public Access Catalogue (OPAC) late 1980s, to the next generation catalog systems (NGC). DL systems are extensively used to...

Università della Svizzera italiana

Predicting failures in complex multi-tier systems

Xin, Rui ; Pezzè, Mauro (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020INFO017.

Complex multi-tier systems are composed of many distributed machines, feature multi-layer architecture and offer different types of services. Shared complex multi-tier systems, such as cloud systems, reduce costs and improves resource utilization efficiency, with a considerable amount of complexity and dynamics that challenge the reliability of the system. The new challenges of complex...

Università della Svizzera italiana

Less is more : efficient hardware design through Approximate Logic Synthesis

Scarabottolo, Ilaria ; Pozzi, Laura (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020INFO023.

As energy efficiency becomes a crucial concern in almost every kind of digital application, Approximate Computing gains popularity as a potential answer to this ever-growing energy quest. Approximate Computing is a design paradigm particularly suited for error- resilient applications, where small losses in accuracy do not represent a significant reduction in the quality of the result. In these...

Université de Fribourg

Neuralink and Beyond: Challenges of Creating an Enhanced Human

Gurtner, Dimitri

(Internal working papers DIUF ; 21-01)

This article is a literature review of Neuralink, brain-machine interfaces (BMIs) and their applications, followed by future possibilities of BMIs and their potential impacts. Currently, BMIs predominantly have therapeutic applications, such as helping people with spinal cord injury by allowing them to control a computer directly with their brain. However, BMIs can also improve learning,...

Università della Svizzera italiana

Retinoic acid sensitivity of triple-negative breast cancer cells characterized by constitutive activation of the NOTCH1 pathway : the role of RARβ

Paroni, Gabriela ; Zanetti, Adriana ; Barzago, Maria Monica ; Kurosaki, Mami ; Guarrera, Luca ; Fratelli, Maddalena ; Troiani, Martina ; Ubezio, Paolo ; Bolis, Marco ; Vallerga, Arianna ; Biancardi, Federica ; Terao, Mineko ; Garattini, Enrico

In: Cancers, 2020, vol. 12, no. 10, p. 23 p

Triple-negative breast cancer (TNBC) is a heterogeneous disease that lacks effective therapeutic options. In this study, we profile eighteen TNBC cell lines for their sensitivity to the anti-proliferative action of all-trans retinoic acid (ATRA). The only three cell lines (HCC-1599, MB- 157 and MDA-MB-157) endowed with ATRA-sensitivity are characterized by genetic aberrations of the NOTCH1-gene,...

Università della Svizzera italiana

Embryological development of the human cranio-facial arterial system : a pictorial review

Bertulli, Lorenzo ; Robert, Thomas

In: Surgical and radiologic anatomy, 2021, p. 13 p

The embryological development of the cerebral vasculature is very complex. Historical and also more recent studies based on human embryos, comparative anatomy and cerebral angiographies allowed us to better understand this vasculature development. The knowledge and understanding of such embryological development are important for physicians interested in neurovascular pathologies. Indeed, all...

Università della Svizzera italiana

Space-time multilevel Monte Carlo methods and their application to cardiac electrophysiology

Ben Bader, Seif ; Benedusi, Pietro ; Quaglino, Alessio ; Zulian, Patrick ; Krause, Rolf

In: Journal of computational physics, 2021, vol. 433, p. 17 p

We present a novel approach aimed at high-performance uncertainty quantification for time-dependent problems governed by partial differential equations. In particular, we consider input uncertainties described by a Karhunen-Loève expansion and compute statistics of high-dimensional quantities-of-interest, such as the cardiac activation potential. Our methodology relies on a close integration...

Università della Svizzera italiana

A transdisciplinary analysis of COVID-19 in Italy : the most affected country in Europe

Ortenzi, Flaminia ; Albanese, Emiliano ; Fadda, Marta

In: International journal of environmental research and public health, 2020, vol. 17, no. 24, p. 12 p

As of 27 March 2020, 199 countries and territories and one international conveyance are affected by the COVID-19 pandemic. As of the same date, Italy represents the third country worldwide in total number of cases and the first one in total number of deaths. The purpose of this study is to analyse the Italian case and identify key problem questions and lessons learned from the Italian...