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Università della Svizzera italiana

Extreme sleep state misperception : from psychopathology to objective-subjective sleep measures

Castelnovo, Anna ; Ferri, Raffaele ; Galbiati, Andrea ; Rossi, Alessandro ; Zucconi, Marco ; Castronovo, Vincenza ; Strambi, Luigi-Ferini ; Manconi, Mauro

In: International journal of psychophysiology, 2021, vol. 167, p. 77-85

Study objectives: We tested the hypothesis that patients with extreme sleep state misperception display higher levels of psychopathology and reduced quantitative estimation abilities compared to other patients with insomnia. Secondary aims included the evaluation of group differences in subjective self-reported quality of life and sleep quality and objective sleep parameters. Methods: In this...

Università della Svizzera italiana

Targeting the DNA damage response for patients with lymphoma : preclinical and clinical evidences

Carrassa, Laura ; Colombo, Ilaria ; Damia, Giovanna ; Bertoni, Francesco

In: Cancer treatment reviews, 2020, vol. 90, p. 11

The DNA damage response (DDR) is a well-coordinated cellular network activated by DNA damage. The unravelling of the key players in DDR, their specific inactivation in different tumor types and the synthesis of specific chemical inhibitors of DDR represent a new hot topic in cancer therapy. In this article, we will review the importance of DDR in lymphoma development and how this can be...

Università della Svizzera italiana

Marine anticancer agents : an overview with a particular focus on their chemical classes

Barreca, Marilia ; Spanò, Virginia ; Montalbano, Alessandra ; Cueto, Mercedes ; Díaz Marrero, Ana R. ; Deniz, Irem ; Erdoğan, Ayşegül ; Lukić Bilela, Lada ; Moulin, Corentin ; Taffin-de-Givenchy, Elisabeth ; Spriano, Filippo ; Perale, Giuseppe ; Mehiri, Mohamed ; Rotter, Ana ; Thomas, Olivier P. ; Barraja, Paola ; Gaudêncio, Susana P. ; Bertoni, Francesco

In: Marine drugs, 2020, vol. 18, no. 12, p. 28

The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from...

Università della Svizzera italiana

Increasing cancer risk over calendar year in people with multiple sclerosis : a case–control study

Zecca, Chiara ; Disanto, Giulio ; Sacco, Rosaria ; MacLachlan, Sharon ; Kuhle, Jens ; Ramagopalan, Sreeram V. ; Gobbi, Claudio

In: Journal of Neurology, 2021, no. 268, p. 817–824

Background: Data on cancer prevalence and incidence in multiple sclerosis (MS) patients are controversial. This study is aimed at estimating cancer risk in MS patients. Methods: Nested case–control study using data collected between 01/01/1987 and 28/02/2016 from the United Kingdom Clinical Practice Research Datalink. Cancer diagnoses after first MS code (index date) was counted in 10,204 MS...

Università della Svizzera italiana

Space–time shape uncertainties in the forward and inverse problem of electrocardiography

Gander, Lia ; Krause, Rolf ; Multerer, Michael ; Pezzuto, Simone

In: International journal for numerical methods in biomedical engineering, 2021, vol. 37, no. 10, p. 23

In electrocardiography, the “classic” inverse problem is the reconstruction of electric potentials at a surface enclosing the heart from remote recordings at the body surface and an accurate description of the anatomy. The latter being affected by noise and obtained with limited resolution due to clinical constraints, a possibly large uncertainty may be perpetuated in the inverse ...

Università della Svizzera italiana

Head-to-head comparison of FNA cytology vs. calcitonin measurement in FNA washout fluids (FNA-CT) to diagnose medullary thyroid carcinoma : A systematic review and meta-analysis

Trimboli, Pierpaolo ; Giannelli, Jacopo ; Marques, Bernardo ; Piccardo, Arnoldo ; Crescenzi, Anna ; Deandrea, Maurilio

In: Endocrine, 2022, no. 75, p. 33–39

Purpose: The sensitivity of cytology after fine needle aspiration (FNA-cytology) in detecting medullary thyroid carcinoma (MTC) is low. To overcome this problem, measuring calcitonin (CT) in washout fluid of FNA (FNA-CT) has been largely diffused and showed good performance. However, no evidence-based study exists comparing systematically the sensitivity of FNA-cytology and FNA-CT. This study...

Università della Svizzera italiana

Neuroticism and internet addiction : What is next? A systematic conceptual review

Marciano, Laura ; Camerini, Anne-Linda ; Schulz, Peter J.

In: Personality and individual differences, 2022, vol. 185, p. 10

The personality trait of neuroticism (N) has consistently shown to be a risk factor for Internet Addiction (IA). Review literature, however, looked at this in bivariate analyses only. To the best of our knowledge, we conducted the first review that systematically and conceptually summarized results based on the inclusion of additional factors, thus coming closer to the complex nature of the ...

Università della Svizzera italiana

RepliComment : Identifying clones in code comments

Blasi, Arianna ; Stulova, Nataliia ; Gorla, Alessandra ; Nierstrasz, Oscar

In: Journal of systems and software, 2021, vol. 182, p. 14

Code comments are the primary means to document implementation and facilitate program comprehension. Thus, their quality should be a primary concern to improve program maintenance. While much effort has been dedicated to detecting bad smells, such as clones in code, little work has focused on comments. In this paper we present our solution to detect clones in comments that developers should...

Università della Svizzera italiana

Maternal psychological distress and children’s internalizing/externalizing problems during the COVID-19 pandemic : the moderating role played by hypermentalization

Bianco, Federica ; Levante, Annalisa ; Petrocchi, Serena ; Lecciso, Flavia ; Castelli, Ilaria

In: International journal of environmental research and public health, 2021, vol. 18, no. 19, p. 17

In order to explore the psychological impact of the COVID‐19 outbreak on the caregiver–child relationship, we investigated the interplay among COVID‐19 exposure and children’s internalizing/externalizing problems during the Italian lockdown, hypothesizing a mediation effect played by maternal distress. Additionally, we included maternal reflective functioning (i.e., hypermentalization)...

Università della Svizzera italiana

Artificial intelligence in thyroid field : a comprehensive review

Bini, Fabiano ; Pica, Andrada ; Azzimonti, Laura ; Giusti, Alessandro ; Ruinelli, Lorenzo ; Marinozzi, Franco ; Trimboli, Pierpaolo

In: Cancers, 2021, vol. 13, no. 19, p. 18

Artificial intelligence (AI) uses mathematical algorithms to perform tasks that require human cognitive abilities. AI-based methodologies, e.g., machine learning and deep learning, as well as the recently developed research field of radiomics have noticeable potential to transform medical diagnostics. AI-based techniques applied to medical imaging allow to detect biological abnormalities, to...