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Methylation of the glucocorticoid receptor promoter in children: Links with parents as teachers, early life stress, and behavior problems

Gardini, Elena Silvia ; Schaub, Simone ; Neuhauser, Alex ; Ramseier, Erich ; Villiger, Arna ; Ehlert, Ulrike ; Lanfranchi, Andrea ; Turecki, Gustavo

In: Development and Psychopathology, 2020, p. 1-13

The present study examined the effect of early life stress (ELS) on the glucocorticoid receptor gene (NR3C1) methylation, the associations between NR3C1 methylation and behavior problems, and the effect of the program Parents as Teachers (PAT) on NR3C1 methylation. Participants included 132 children, 72 assigned to the PAT intervention group and 60 to the PAT control group. Children were...