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    Université de Fribourg

    A guide to investigating colloidal nanoparticles by cryogenic transmission electron microscopy: pitfalls and benefits

    Monnier, Christophe A. ; Thévenaz, David C. ; Balog, Sandor ; Fiore, Gina L. ; Vanhecke, Dimitri ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

    In: AIMS Biophysics, 2015, vol. 2, no. 3, p. 245–258

    Synthetic colloidal nanoparticles are nowadays omnipresent. Nonetheless, adequately characterizing them and interpreting the data is challenging, as their surrounding environment, e.g. the medium they are dispersed in, is often an active contributor to their size, morphology and structural integrity. In this regard, cryo-transmission electron microscopy (cryo-TEM) is an ideal methodology. This...