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    Université de Fribourg

    Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures

    Schwaller, Beat ; Tetko, I. V. ; Tandon, P. ; Silveira, D. C. ; Vreugdenhil, M. ; Henzi, Thomas ; Potier, M. -C. ; Celio, Marco R. ; Villa, A. E. P.

    In: Molecular and Cellular Neuroscience, 2004, vol. 24(4), p. 650

    Networks of GABAergic interneurons are of utmost importance in generating and promoting synchronous activity and are involved in producing coherent oscillations. These neurons are characterized by their fast-spiking rate and by the expression of the Ca²⁺-binding protein parvalbumin (PV). Alteration of their inhibitory activity has been proposed as a major mechanism leading to epileptic...

    Université de Fribourg

    Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures

    Schwaller, Beat ; Tetko, I. V. ; Tandon, P. ; Silveira, D. C. ; Vreugdenhil, M. ; Henzi, Thomas ; Potier, M. -C. ; Celio, Marco R. ; Villa, A. E. P.

    In: Molecular and Cellular Neuroscience, 2004, vol. 25(4), p. 650-663

    Networks of GABAergic interneurons are of utmost importance in generating and promoting synchronous activity and are involved in producing coherent oscillations. These neurons are characterized by their fast-spiking rate and by the expression of the Ca2+-binding protein parvalbumin (PV). Alteration of their inhibitory activity has been proposed as a major mechanism leading to epileptic seizures...