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Université de Fribourg

Acute alcohol intoxication and expectations reshape the spatiotemporal functional architecture of executive control

Ribordy Lambert, Farfalla ; Wicht, Corentin A. ; Mouthon, Michael ; Spierer, Lucas

In: NeuroImage, 2020, vol. 215, p. 116811

While the deleterious effects of acute ethyl alcohol intoxication on executive control are well-established, the underlying spatiotemporal brain mechanisms remain largely unresolved. In addition, since the effects of alcohol are noticeable to participants, isolating the effects of the substance from those related to expectations represents a major challenge. We addressed these issues using a...

Université de Fribourg

Stimulus reward value interacts with training-induced plasticity in inhibitory control

Pretto, Michael De ; Hartmann, Lea ; Garcia-Burgos, David ; Sallard, Etienne ; Spierer, Lucas

In: Neuroscience, 2019, vol. 421, p. 82–94

Training inhibitory control, the ability to suppress motor or cognitive processes, not only enhances inhibition processes, but also reduces the perceived value and behaviors toward the stimuli associated with the inhibition goals during the practice. While these findings suggest that inhibitory control training interacts with the aversive and reward systems, the underlying spatio-temporal...

Université de Fribourg

Executive control training does not generalize, even when associated with plastic changes in domain-general prefrontal areas

Simonet, Marie ; Crettaz von Roten, Fabienne ; Spierer, Lucas ; Barral, Jérôme

In: NeuroImage, 2019, vol. 197, p. 457–469

How executive function training paradigms can be effectively designed to promote a transfer of the effects of interventions to untrained tasks remains unclear. Here, we tested the hypothesis that training with a complex task involving motor, perceptual and task-set control components would result in more transfer than training with a simple motor control task, because the Complex training...

Université de Fribourg

Practice-induced functional plasticity in inhibitory control interacts with aging

Hartmann, Lea ; Wachtl, Laura ; Lucia, Marzia de ; Spierer, Lucas

In: Brain and Cognition, 2019, vol. 132, p. 22–32

Inhibitory control deficits represent a key aspect of the cognitive declines associated with aging. Practicing inhibitory control has thus been advanced as a potential approach to compensate for age-induced neurocognitive impairments. Yet, the functional brain changes associated with practicing inhibitory control tasks in older adults and whether they differ from those observed in young...

Université de Fribourg

Spatiotemporal brain dynamics underlying attentional bias modifications

Sallard, Etienne ; Hartmann, Lea ; Ptak, Radek ; Spierer, Lucas

In: International Journal of Psychophysiology, 2018, vol. 130, p. 29–39

Exaggerated attentional biases toward specific elements of the environment contribute to the maintenance of several psychiatric conditions, such as biases to threatening faces in social anxiety. Although recent literature indicates that attentional bias modification may constitute an effective approach for psychiatric remediation, the underlying neurophysiological mechanisms remain unclear....

Université de Fribourg

Dorsolateral prefrontal transcranial direct current stimulation modulates language processing but does not facilitate overt second language word production

Radman, Narges ; Britz, Juliane ; Buetler, Karin ; Weekes, Brendan S. ; Spierer, Lucas ; Annoni, Jean-Marie

In: Frontiers in Neuroscience, 2018, vol. 12, p. -

Word retrieval in bilingual speakers partly depends on executive-control systems in the left prefrontal cortex - including dorsolateral prefrontal cortex (DLPFC). We tested the hypothesis that DLPFC modulates word production of words specifically in a second language (L2) by measuring the effects of anodal transcranial direct current stimulation (anodal-tDCS) over the DLPFC on picture naming...

Université de Fribourg

Modulation of inhibitory control by prefrontal anodal tDCS: A crossover double-blind sham-controlled fMRI study

Sallard, Etienne ; Mouthon, Michael ; De Pretto, Michael ; Spierer, Lucas

In: PLOS ONE, 2018, vol. 13, no. 3, p. e0194936

Prefrontal anodal transcranial direct current stimulation (tDCS) has been proposed as a potential approach to improve inhibitory control performance. The functional consequences of tDCS during inhibition tasks remain, however, largely unresolved. We addressed this question by analyzing functional magnetic resonance imaging (fMRI) recorded while participants completed a Go/NoGo task after...

Université de Fribourg

Spatiotemporal brain dynamics supporting the immediate automatization of inhibitory control by implementation intentions

De Pretto, Michael ; Rochat, Lucien ; Spierer, Lucas

In: Scientific Reports, 2017, vol. 7, no. 1, p. 10821

While cognitive interventions aiming at reinforcing intentional executive control of unwanted response showed only modest effects on impulse control disorders, the establishment of fast automatic, stimulus-driven inhibition of responses to specific events with implementation intention self-regulation strategies has proven to be an effective remediation approach. However, the neurocognitive...