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Université de Fribourg

Silica nanoparticles enhance disease resistance in Arabidopsis plants

El-Shetehy, Mohamed ; Moradi, Aboubakr ; Maceroni, Mattia ; Reinhardt, Didier ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Mauch, Felix ; Schwab, Fabienne

In: Nature Nanotechnology, 2020, p. 1–10

In plants, pathogen attack can induce an immune response known as systemic acquired resistance that protects against a broad spectrum of pathogens. In the search for safer agrochemicals, silica nanoparticles (SiO2 NPs; food additive E551) have recently been proposed as a new tool. However, initial results are controversial, and the molecular mechanisms of SiO2 NP-induced disease resistance...

Université de Fribourg

A Phytophthora effector protein promotes symplastic cell-to-cell trafficking by physical interaction with plasmodesmata-localised callose synthases

Tomczynska, Iga ; Stumpe, Michael ; Doan, Tu Giang ; Mauch, Felix

In: New Phytologist, 2020, p. -

Pathogen effectors act as disease promoting factors that target specific host proteins with roles in plant immunity. Here, we investigated the function of the RxLR3 effector of the plant‐pathogen Phytophthora brassicae .Arabidopsis plants expressing a FLAG‐ RxLR3 fusion protein were used for co‐immunoprecipitation followed by liquid chromatography‐tandem mass spectrometry to identify...

Université de Fribourg

The potential of antagonistic moroccan Streptomyces isolates for the biological control of damping-off disease of pea (Pisum sativum L.) caused by Aphanomyces euteiches

Oubaha, Brahim ; Nafis, Ahmed ; Baz, Mohamed ; Mauch, Felix ; Barakate, Mustapha

In: Journal of Phytopathology, 2019, vol. 167, no. 2, p. 82–90

Three hundred and fifty‐nine isolates of actinobacteria collected from different Moroccan soils were evaluated for their in vitro antimicrobial activity against the oomycete pathogen Aphanomyces euteiches, the causal agent of damping‐off of pea and other legumes. Eighty‐seven isolates (24%) had an inhibitory in vitro effect against A. euteiches. Fourteen bioactive isolates with the...

Université de Fribourg

A conserved RxLR effector interacts with host RABA-type GTPases to inhibit vesicle-mediated secretion of antimicrobial proteins

Tomczynska, Iga ; Stumpe, Michael ; Mauch, Felix

In: The Plant Journal, 2018, vol. 95, no. 2, p. 187–203

Plant pathogens of the oomycete genus Phytophthora produce virulence factors, known as RxLR effector proteins that are transferred into host cells to suppress disease resistance. Here, we analyse the function of the highly conserved RxLR24 effector of Phytophthora brassicae. RxLR24 was expressed early in the interaction with Arabidopsis plants and ectopic expression in the host enhanced leaf...

Université de Fribourg

The sterol-binding activity of PATHOGENESIS-RELATED PROTEIN 1 reveals the mode of action of an antimicrobial protein

Gamir, Jordi ; Darwiche, Rabih ; Hof, Pieter van't ; Choudhary, Vineet ; Stumpe, Michael ; Schneiter, Roger ; Mauch, Felix

In: The Plant Journal, 2017, vol. 89, no. 3, p. 502–509

Pathogenesis-related proteins played a pioneering role 50 years ago in the discovery of plant innate immunity as a set of proteins that accumulated upon pathogen challenge. The most abundant of these proteins, PATHOGENESIS-RELATED 1 (PR-1) encodes a small antimicrobial protein that has become, as a marker of plant immune signaling, one of the most referred to plant proteins. The biochemical...

Université de Fribourg

Protein phosphatase AP2C1 negatively regulates basal resistance and defense responses to Pseudomonas syringae

Shubchynskyy, Volodymyr ; Boniecka, Justyna ; Schweighofer, Alois ; Simulis, Justinas ; Kvederaviciute, Kotryna ; Stumpe, Michael ; Mauch, Felix ; Balazadeh, Salma ; Mueller-Roeber, Bernd ; Boutrot, Freddy ; Zipfel, Cyril ; Meskiene, Irute

In: Journal of Experimental Botany, 2017, p. -

Mitogen-activated protein kinases (MAPKs) mediate plant immune responses to pathogenic bacteria. However, less is known about the cell autonomous negative regulatory mechanism controlling basal plant immunity. We report the biological role of Arabidopsis thaliana MAPK phosphatase AP2C1 as a negative regulator of plant basal resistance and defense responses to Pseudomonas syringae. AP2C2, a...

Université de Fribourg

Regulatory and functional aspects of indolic metabolism in plant systemic acquired resistance

Stahl, Elia ; Bellwon, Patricia ; Huber, Stefan ; Schlaeppi, Klaus ; Bernsdorff, Friederike ; Vallat-Michel, Armelle ; Mauch, Felix ; Zeier, Jürgen

In: Molecular Plant, 2016, p. -

Tryptophan-derived, indolic metabolites possess diverse functions in Arabidopsis innate immunity to microbial pathogen infection. Here, we investigate the functional role and regulatory characteristics of indolic metabolism in Arabidopsis systemic acquired resistance (SAR) triggered by the bacterial pathogen Pseudomonas syringae. Indolic metabolism is broadly activated in both P....

Université de Fribourg

export of salicylic acid from the chloroplast requires the multidrug and toxin extrusion-Like transporter EDS5

Serrano, Mario ; Wang, Bangjun ; Aryal, Bibek ; Garcion, Christophe ; Abou-Mansour, Eliane ; Heck, Silvia ; Geisler, Markus ; Mauch, Felix ; Nawrath, Christiane ; Métraux, Jean-Pierre

In: Plant Physiology, 2013, vol. 162, no. 4, p. 1815–1821

Salicylic acid (SA) is central for the defense of plants to pathogens and abiotic stress. SA is synthesized in chloroplasts from chorismic acid by an isochorismate synthase (ICS1); SA biosynthesis is negatively regulated by autoinhibitory feedback at ICS1. Genetic studies indicated that the multidrug and toxin extrusion transporter ENHANCED DISEASE SUSCEPTIBILITY5 (EDS5) of Arabidopsis...

Université de Fribourg

Glutathione deficiency of the Arabidopsis mutant pad2-1 affects oxidative stress-related events, defense gene expression, and the hypersensitive response

Dubreuil-Maurizi, Carole ; Vitecek, Jan ; Marty, Laurent ; Branciard, Lorelise ; Frettinger, Patrick ; Wendehenne, David ; Meyer, Andreas J. ; Mauch, Felix ; Poinssot, Benoît

In: Plant Physiology, 2011, vol. 157, no. 4, p. 2000-2012

The Arabidopsis (Arabidopsis thaliana) phytoalexin-deficient mutant pad2-1 displays enhanced susceptibility to a broad range of pathogens and herbivorous insects that correlates with deficiencies in the production of camalexin, indole glucosinolates, and salicylic acid (SA). The pad2-1 mutation is localized in the GLUTAMATE-CYSTEINE LIGASE (GCL) gene encoding the first enzyme of glutathione...