Université de Fribourg

Role of the thalamus in basal forebrain regulation of neural activity in the primary auditory cortex

Azimi, Hamid ; Klaassen, Arndt-Lukas ; Thomas, Kevin ; Harvey, Michael A. ; Rainer, Gregor

In: Cerebral Cortex, 2020, vol. 30, no. 8, p. 4481–4495

Many studies have implicated the basal forebrain (BF) as a potent regulator of sensory encoding even at the earliest stages of or cortical processing. The source of this regulation involves the well-documented corticopetal cholinergic projections from BF to primary cortical areas. However, the BF also projects to subcortical structures, including the thalamic reticular nucleus (TRN), which...

Université de Fribourg

Basal forebrain contributes to default mode network regulation

Nair, Jayakrishnan ; Klaassen, Arndt-Lukas ; Arato, Jozsef ; Vyssotski, Alexei L. ; Harvey, Michael ; Rainer, Gregor

In: Proceedings of the National Academy of Sciences, 2018, vol. 115, no. 6, p. 1352–1357

The default mode network (DMN) is a collection of cortical brain regions that is active during states of rest or quiet wakefulness in humans and other mammalian species. A pertinent characteristic of the DMN is a suppression of local field potential gamma activity during cognitive task performance as well as during engagement with external sensory stimuli. Conversely, gamma activity is...

Université de Fribourg

Gamma band directional interactions between basal forebrain and visual cortex during wake and sleep states

Nair, Jayakrishnan ; Klaassen, Arndt-Lukas ; Poirot, Jordan ; Vyssotski, Alexei ; Rasch, Björn ; Rainer, Gregor

In: Journal of Physiology-Paris, 2016, vol. 110, no. 1–2, p. 19–28

The basal forebrain (BF) is an important regulator of cortical excitability and responsivity to sensory stimuli, and plays a major role in wake-sleep regulation. While the impact of BF on cortical EEG or LFP signals has been extensively documented, surprisingly little is known about LFP activity within BF. Based on bilateral recordings from rats in their home cage, we describe endogenous LFP...