Refine my results

Document type

Specific Collection


Université de Fribourg

Granzyme B attenuates bacterial virulence by targeting secreted factors

López León, Diego ; Matthey, Patricia ; Fellay, Isabelle ; Blanchard, Marianne ; Martinvalet, Denis ; Mantel, Pierre-Yves ; Filgueira, Luis ; Walch, Michael

In: iScience, 2020, vol. 23, no. 3, p. 100932

Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to contribute crucially to antibacterial defense. Here we show that granzyme B degrades multiple secreted virulence mediators from Listeria monocytogenes,...

Université de Fribourg

Anatomic analysis of the internal and external aspects of the pterion

Uz, Aysun ; Korkmaz, Ali Can ; Filgueira, Luis ; Guner, Mehmet Ali ; Tubbs, Richard Shane ; Demirciler, Ayse Karatas

In: World Neurosurgery, 2020, vol. 137, p. 84–88

Objective: The pterion is an H-shaped suture complex. This study's goal was to determine the location of its external and internal surfaces and extension and emphasize and discuss its surgical importance.Methods: Fifty dried adult human skulls were obtained from the Department of Anatomy. A 2-mm drill bit was placed externally over the pterion, and the pterion was drilled through the bone...

Université de Fribourg

γδ T cells kill Plasmodium falciparum in a granzyme- and granulysin-dependent mechanism during the late blood stage

Hernández-Castañeda, Maria Andrea ; Happ, Katharina ; Cattalani, Filippo ; Wallimann, Alexandra ; Blanchard, Marianne ; Fellay, Isabelle ; Scolari, Brigitte ; Lannes, Nils ; Mbagwu, Smart Ikechukwu ; Fellay, Benoît ; Filgueira, Luis ; Mantel, Pierre-Yves ; Walch, Michael

In: The Journal of Immunology, 2020, vol. 204, no. 7, p. 1798–1809

Plasmodium spp., the causative agent of malaria, have a complex life cycle. The exponential growth of the parasites during the blood stage is responsible for almost all malaria-associated morbidity and mortality. Therefore, tight immune control of the intraerythrocytic replication of the parasite is essential to prevent clinical malaria. Despite evidence that the particular lymphocyte subset ...

Université de Fribourg

Human microglia respond to malaria-induced extracellular vesicles

Mbagwu, Smart Ikechukwu ; Lannes, Nils ; Walch, Michael ; Filgueira, Luis ; Mantel, Pierre-Yves

In: Pathogens, 2020, vol. 9, no. 1, p. 21

Microglia are the chief immune cells of the brain and have been reported to be activated in severe malaria. Their activation may drive towards neuroinflammation in cerebral malaria. Malaria-infected red blood cell derived-extracellular vesicles (MiREVs) are produced during the blood stage of malaria infection. They mediate intercellular communication and immune regulation, among other...

Université de Fribourg

Differential expression of CD31 and von Willebrand factor on endothelial cells in different regions of the human brain: potential implications for cerebral malaria pathogenesis

Mbagwu, Smart Ikechukwu ; Filgueira, Luis

In: Brain Sciences, 2020, vol. 10, no. 1, p. 31

Cerebral microvascular endothelial cells (CMVECs) line the vascular system of the brain and are the chief cells in the formation and function of the blood brain barrier (BBB). These cells are heterogeneous along the cerebral vasculature and any dysfunctional state in these cells can result in a local loss of function of the BBB in any region of the brain. There is currently no report on the...

Université de Fribourg

Innervation of the clavicular part of the deltoid muscle by the lateral pectoral nerve

Larionov, Alexey ; Yotovski, Peter ; Link, Karl ; Filgueira, Luis

In: Clinical Anatomy, 2020, vol. 33, no. 8, p. 1152-1158

The innervation pattern of the clavicular head of the deltoid muscle and its corresponding topography was investigated via cadaveric dissection in the present study, focusing on the lateral pectoral nerve.Materials and methods: Fifty‐eight upper extremities were dissected and the nerve supplies to the deltoid muscle and the variability of the lateral pectoral and axillary nerves, including...

Université de Fribourg

Review of emerging japanese encephalitis virus: new aspects and concepts about entry into the brain and inter-cellular spreading

Filgueira, Luis ; Lannes, Nils

In: Pathogens, 2019, vol. 8, no. 3, p. 111

Japanese encephalitis virus (JEV) is an emerging flavivirus of the Asia-Pacific region. More than two billion people live in endemic or epidemic areas and are at risk of infection. Recently, the first autochthonous human case was recorded in Africa, and infected birds have been found in Europe. JEV may spread even further to other continents. The first section of this review covers...

Université de Fribourg

CX 3 CR1-CX 3 CL1-dependent cell-to-cell Japanese encephalitis virus transmission by human microglial cells

Lannes, Nils ; Garcia-Nicolàs, Obdullio ; Démoulins, Thomas ; Summerfield, Artur ; Filgueira, Luis

In: Scientific Reports, 2019, vol. 9, no. 1, p. 4833

The neurotropic Japanese encephalitis virus (JEV) is responsible for Japanese encephalitis, an uncontrolled inflammatory disease of the central nervous system. Microglia cells are the unique innate immune cell type populating the brain that cross- communicate with neurons via the CX3CR1-CX3CL1 axis. However, microglia may serve as a viral reservoir for JEV. Human microglia are able to transmit...

Université de Fribourg

Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system

Lannes, Nils ; Eppler, Elisabeth ; Etemad, Samar ; Yotovski, Peter ; Filgueira, Luis

In: Oncotarget, 2017, vol. 8, no. 69, p. 114393–114413

Microglia cells are the unique residential macrophages of the central nervous system (CNS). They have a special origin, as they derive from the embryonic yolk sac and enter the developing CNS at a very early stage. They play an important role during CNS development and adult homeostasis. They have a major contribution to adult neurogenesis and neuroinflammation. Thus, they participate in the...

Université de Fribourg

Evaluation of extracellular vesicle function during malaria infection

Andrea Hernández-Castañeda, María ; Mbagwu, Smart Ikechukwu ; Babatunde, Kehinde Adebayo ; Walch, Michael ; Filgueira, Luis ; Mantel, Pierre-Yves

In: JoVE (Journal of Visualized Experiments), 2018, no. 132, p. e57067

Malaria is a life-threatening disease caused by Plasmodium parasites, with P. falciparum being the most prevalent on the African continent and responsible for most malaria-related deaths globally. Several factors including parasite sequestration in tissues, vascular dysfunction, and inflammatory responses influence the evolution of the disease in malaria-infected people. P. falciparum-infected...