Università della Svizzera italiana

Increasing cancer risk over calendar year in people with multiple sclerosis : a case–control study

Zecca, Chiara ; Disanto, Giulio ; Sacco, Rosaria ; MacLachlan, Sharon ; Kuhle, Jens ; Ramagopalan, Sreeram V. ; Gobbi, Claudio

In: Journal of Neurology, 2021, no. 268, p. 817–824

Background: Data on cancer prevalence and incidence in multiple sclerosis (MS) patients are controversial. This study is aimed at estimating cancer risk in MS patients. Methods: Nested case–control study using data collected between 01/01/1987 and 28/02/2016 from the United Kingdom Clinical Practice Research Datalink. Cancer diagnoses after first MS code (index date) was counted in 10,204 MS...

Università della Svizzera italiana

Contribution of sleep disturbances to fatigue in multiple sclerosis : a prospective study using clinical and polysomnographic parameters

Riccitelli, Gianna C. ; Disanto, Giulio ; Sacco, Rosaria ; Sparasci, Davide ; Sacco, Leonardo ; Castelnovo, Anna ; Miano, Silvia ; Manconi, Mauro ; Gobbi, Claudio ; Zecca, Chiara

In: European journal of neurology, 2021, vol. 28, no. 9, p. 9

Background and purpose: Fatigue is amongst the most frequent and disabling symptoms of multiple sclerosis and a close relation between fatigue and sleep quality has been hypothesized. In this study the contribution of sleep disturbances measured by clinical and polysomnographic parameters to fatigue in multiple sclerosis was investigated. Methods: This was a prospective instrumental study...