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Université de Fribourg

Phosphorylation and circadian molecular timing

Brenna, Andrea ; Albrecht, Urs

In: Frontiers in Physiology, 2020, vol. 11, p. -

Endogenous circadian rhythms are biological processes generated by an internal body clock. They are self-sustaining, and they govern biochemical and physiological processes. However, circadian rhythms are influenced by many external stimuli to reprogram the phase in response to environmental change. Through their adaptability to environmental changes, they synchronize physiological responses...

Université de Fribourg

The past and future human impact on mammalian diversity

Andermann, Tobias ; Faurby, Søren ; Turvey, Samuel T. ; Antonelli, Alexandre ; Silvestro, Daniele

In: Science Advances, 2020, vol. 6, no. 36, p. eabb2313

To understand the current biodiversity crisis, it is crucial to determine how humans have affected biodiversity in the past. However, the extent of human involvement in species extinctions from the Late Pleistocene onward remains contentious. Here, we apply Bayesian models to the fossil record to estimate how mammalian extinction rates have changed over the past 126,000 years, inferring...

Université de Fribourg

Genomic footprints of repeated evolution of CAM photosynthesis in a Neotropical species radiation

De La Harpe, Marylaure ; Paris, Margot ; Hess, Jaqueline ; Barfuss, Michael Harald Johannes ; Serrano‐Serrano, Martha Liliana ; Ghatak, Arindam ; Chaturvedi, Palak ; Weckwerth, Wolfram ; Till, Walter ; Salamin, Nicolas ; Wai, Ching Man ; Ming, Ray ; Lexer, Christian

In: Plant, Cell & Environment, 2020/n/a//-

The adaptive radiation of Bromeliaceae (pineapple family) is one of the most diverse among Neotropical flowering plants. Diversification in this group was facilitated by shifts in several adaptive traits or “key innovations” including the transition from C3 to CAM photosynthesis associated with xeric (heat/drought) adaptation. We used phylogenomic approaches, complemented by differential...

Université de Fribourg

Multiple cryoinjuries modulate the efficiency of zebrafish heart regeneration

Bise, Thomas ; Sallin, Pauline ; Pfefferli, Catherine ; Jaźwińska, Anna

In: Scientific Reports, 2020, vol. 10, no. 1, p. 11551

Zebrafish can regenerate their damaged hearts throughout their lifespan. It is, however, unknown, whether regeneration remains effective when challenged with successive cycles of cardiac damage in the same animals. Here, we assessed ventricular restoration after two, three and six cryoinjuries interspaced by recovery periods. Using transgenic cell-lineage tracing analysis, we demonstrated...

Université de Fribourg

A new species of baenid turtle from the Early Cretaceous Lakota Formation of South Dakota

Joyce, Walter G. ; Rollot, Yann ; Cifelli, Richard L.

In: Fossil Record, 2020, vol. 23, no. 1, p. 1–13

Baenidae is a clade of paracryptodiran turtles known from the late Early Cretaceous to Eocene of North America. The proposed sister-group relationship of Baenidae to Pleurosternidae, a group of turtles known from sediments dated as early as the Late Jurassic, suggests a ghost lineage that crosses the early Early Cretaceous. We here document a new species of paracryptodiran turtle, Lakotemys...

Université de Fribourg

Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock

Brenna, Andrea ; Olejniczak, Iwona ; Chavan, Rohit ; Ripperger, Jürgen A. ; Langmesser, Sonja ; Cameroni, Elisabetta ; Hu, Zehan ; De Virgilio, Claudio ; Dengjel, Jörn ; Albrecht, Urs

In: eLife, 2019, vol. 8, p. e50925

Circadian oscillations emerge from transcriptional and post-translational feedback loops. An important step in generating rhythmicity is the translocation of clock components into the nucleus, which is regulated in many cases by kinases. In mammals, the kinase promoting the nuclear import of the key clock component Period 2 (PER2) is unknown. Here, we show that the cyclin-dependent kinase 5...

Université de Fribourg

Ancient mitogenomics clarifies radiation of extinct Mascarene giant tortoises ( Cylindraspis spp.)

Kehlmaier, Christian ; Graciá, Eva ; Campbell, Patrick D. ; Hofmeyr, Margaretha D. ; Schweiger, Silke ; Martínez-Silvestre, Albert ; Joyce, Walter G. ; Fritz, Uwe

In: Scientific Reports, 2019, vol. 9, no. 1, p. 1-7

The five extinct giant tortoises of the genus Cylindraspis belong to the most iconic species of the enigmatic fauna of the Mascarene Islands that went largely extinct after the discovery of the islands. To resolve the phylogeny and biogeography of Cylindraspis, we analysed a data set of 45 mitogenomes that includes all lineages of extant tortoises and eight near-complete sequences of all...