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Université de Fribourg

Circadian and genetic modulation of visually-guided navigation in Drosophila larvae

Asirim, Ece Z. ; Humberg, Tim-Henning ; Maier, G. Larisa ; Sprecher, Simon G.

In: Scientific Reports, 2020, vol. 10, no. 1, p. 2752

Organisms possess an endogenous molecular clock which enables them to adapt to environmental rhythms and to synchronize their metabolism and behavior accordingly. Circadian rhythms govern daily oscillations in numerous physiological processes, and the underlying molecular components have been extensively described from fruit flies to mammals. Drosophila larvae have relatively simple nervous...

Université de Fribourg

Multiple cryoinjuries modulate the efficiency of zebrafish heart regeneration

Bise, Thomas ; Sallin, Pauline ; Pfefferli, Catherine ; Jaźwińska, Anna

In: Scientific Reports, 2020, vol. 10, no. 1, p. 11551

Zebrafish can regenerate their damaged hearts throughout their lifespan. It is, however, unknown, whether regeneration remains effective when challenged with successive cycles of cardiac damage in the same animals. Here, we assessed ventricular restoration after two, three and six cryoinjuries interspaced by recovery periods. Using transgenic cell-lineage tracing analysis, we demonstrated...

Université de Fribourg

Towards deciphering variations of heart regeneration in fish

Jaźwińska, Anna ; Blanchoud, Simon

In: Current Opinion in Physiology, 2020, vol. 14, p. 21–26

Among adult vertebrates, the zebrafish presents the rather exceptional capacity to efficiently regenerate its heart after injury. This bony fish has thus become a leading genetic model organism to elucidate the natural mechanisms of successful cardiac restoration. Given its potential biomedical significance, parallel analyses between zebrafish and mammals are aiming at the identification of...

Université de Fribourg

Distribution and restoration of serotonin-immunoreactive paraneuronal cells during caudal fin regeneration in zebrafish

König, Désirée ; Dagenais, Paule ; Senk, Anita ; Djonov, Valentin ; Aegerter, Christof M. ; Jaźwińska, Anna

In: Frontiers in Molecular Neuroscience, 2019, vol. 12, p. -

Aquatic vertebrates possess diverse types of sensory cells in their skin to detect stimuli in the water. In the adult zebrafish, a common model organism, the presence of such cells in fins has only rarely been studied. Here, we identified scattered serotonin (5-HT)-positive cells in the epidermis of the caudal fin. These cells were distinct from keratinocytes as revealed by their low...

Université de Fribourg

Silver(I) complexes with 4,7-phenanthroline efficient in rescuing the zebrafish embryos of lethal Candida albicans infection

Pavic, Aleksandar ; Savić, Nada D. ; Glišić, Biljana Đ. ; Crochet, Aurélien ; Vojnovic, Sandra ; Kurutos, Atanas ; Stanković, Dalibor M. ; Fromm, Katharina M. ; Nikodinovic-Runic, Jasmina ; Djuran, Miloš I.

In: Journal of Inorganic Biochemistry, 2019, vol. 195, p. 149–163

Five novel silver(I) complexes with 4,7-phenanthroline (4,7-phen), [Ag(NO3-O)(4,7- phen-μ-N4,N7)]n (1), [Ag(ClO4-О)(4,7-phen-μ-N4,N7)]n (2), [Ag(CF3COO-O)(4,7- phen-μ-N4,N7)]n (3), [Ag2(H2O)0.58(4,7-phen)3](SbF6)2 (4) and {[Ag2(H2O)(4,7- phen-μ-N4,N7)2](BF4)2}n (5) were synthesized, structurally elucidated and biologically evaluated. These complexes showed selectivity towards Candida spp....