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Université de Fribourg

Phosphoproteomic profiling reveals a defined genetic program for osteoblastic lineage commitment of human bone marrow–derived stromal stem cells

Barrio-Hernandez, Inigo ; Jafari, Abbas ; Rigbolt, Kristoffer T.G. ; Hallenborg, Philip ; Sanchez-Quiles, Virginia ; Skovrind, Ida ; Akimov, Vyacheslav ; Kratchmarova, Irina ; Dengjel, Jörn ; Kassem, Moustapha ; Blagoev, Blagoy

In: Genome Research, 2020, vol. 30, no. 1, p. 127-137

Bone marrow–derived mesenchymal stem cells (MSCs) differentiate into osteoblasts upon stimulation by signals present in their niche. Because the global signaling cascades involved in the early phases of MSCs osteoblast (OB) differentiation are not well-defined, we used quantitative mass spectrometry to delineate changes in human MSCs proteome and phosphoproteome during the first 24 h of...

Université de Fribourg

Kin-dependent dispersal influences relatedness and genetic structuring in a lek system

Cayuela, Hugo ; Boualit, Laurent ; Laporte, Martin ; Prunier, Jérôme G. ; Preiss, Françoise ; Laurent, Alain ; Foletti, Francesco ; Clobert, Jean ; Jacob, Gwenaël

In: Oecologia, 2019, vol. 191, no. 1, p. 97–112

Kin selection and dispersal play a critical role in the evolution of cooperative breeding systems. Limited dispersal increases relatedness in spatially structured populations (population viscosity), with the result that neighbours tend to be genealogical relatives. Yet the increase in neighbours’ fitness-related performance through altruistic interaction may also result in habitat...

Consortium of Swiss Academic Libraries

The dietary protein, IGF-I, skeletal health axis

Bonjour, Jean-Philippe

In: Hormone Molecular Biology and Clinical Investigation, 2016, vol. 28, no. 1, p. 39-53