In: Sleep, 2016, vol. 39, no. 3, p. 589-601
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In: The Journal of Clinical Endocrinology & Metabolism, 2018, vol. 103, no. 8, p. 2988-2997
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In: Sleep, 2016, vol. 39, no. 4, p. 875-885
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In: Journal of Inherited Metabolic Disease, 2015, vol. 38, no. 6, p. 1075-1083
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In: Bioinformatics, 2016, vol. 32, no. 6, p. 875-883
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In: Pharmacology, 2020, vol. 105, no. 9–10, p. 491–504
Background: Adipose tissue inflammation occurs not only in obesity but also in aging and is mechanistically linked with age-associated diseases. Studies show that ablation of the l-arginine-metabolizing enzyme arginase-II (Arg-II) reduces adipose tissue inflammation and improves glucose tolerance in obesity. However, the role of Arg-II in aging adipose tissue inflammation is not clear....
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In: Shock, 2020, vol. 53, no. 5, p. 653–665
Objective: Activation of the constitutive nuclear and mitochondrial enzyme poly (ADP- ribose) polymerase (PARP) has been implicated in the pathogenesis of cell dysfunction, inflammation, and organ failure in various forms of critical illness. The objective of our study was to evaluate the efficacy and safety of the clinically approved PARP inhibitor olaparib in an experimental model of...
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In: Published version; http://dx.doi.org/10.1007/s11357-019-00095-x, 2019, p. -
Understanding molecular mechanisms involved in vascular aging is essential to develop novel interventional strategies for treatment and prevention of age-related vascular pathologies. Recent studies provide critical evidence that vascular aging is characterized by NAD+ depletion. Importantly, in aged mice, restoration of cellular NAD+ levels by treatment with the NAD+ booster nicotinamide...
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In: Basic Research in Cardiology, 2014, vol. 109, no. 1, p. 1-15
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In: Internal and Emergency Medicine, 2014, vol. 9, no. 4, p. 411-417
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