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Université de Fribourg

Biophysics of temporal interference stimulation

Mirzakhalili, Ehsan ; Barra, Beatrice ; Capogrosso, Marco ; Lempka, Scott F.

In: Cell Systems, 2020, vol. 11, no. 6, p. 557-572.e5

Temporal interference (TI) is a non-invasive neurostimulation technique that utilizes high-frequency external electric fields to stimulate deep neuronal structures without affecting superficial, off-target structures. TI represents a potential breakthrough for treating conditions, such as Parkinson’s disease and chronic pain. However, early clinical work on TI stimulation was met with mixed...

Université de Fribourg

Genomic footprints of repeated evolution of CAM photosynthesis in a Neotropical species radiation

De La Harpe, Marylaure ; Paris, Margot ; Hess, Jaqueline ; Barfuss, Michael Harald Johannes ; Serrano‐Serrano, Martha Liliana ; Ghatak, Arindam ; Chaturvedi, Palak ; Weckwerth, Wolfram ; Till, Walter ; Salamin, Nicolas ; Wai, Ching Man ; Ming, Ray ; Lexer, Christian

In: Plant, Cell & Environment, 2020/n/a//-

The adaptive radiation of Bromeliaceae (pineapple family) is one of the most diverse among Neotropical flowering plants. Diversification in this group was facilitated by shifts in several adaptive traits or “key innovations” including the transition from C3 to CAM photosynthesis associated with xeric (heat/drought) adaptation. We used phylogenomic approaches, complemented by differential...

Université de Fribourg

The transcription factor Spt4-Spt5 complex regulates the expression of ATG8 and ATG41

Wen, Xin ; Gatica, Damián ; Yin, Zhangyuan ; Hu, Zehan ; Dengjel, Jörn ; Klionsky, Daniel J.

In: Autophagy, 2019, vol. 0, no. 0, p. 1–14

Macroautophagy/autophagy, a highly conserved dynamic process, is one of the major degradative pathways in cells. So far, over 40 autophagy-related (ATG) genes have been identified in Saccharomyces cerevisiae, most of which have homologs in more complex eukaryotes. Autophagy plays a crucial role in cell survival and maintenance, and its dysfunction is related to various diseases, indicating...