Ergebnisse einschränken

Unstable argininosuccinate lyase in variant forms of the urea cycle disorder argininosuccinic aciduria

Hu, Liyan ; Pandey, Amit ; Balmer, Cécile ; Eggimann, Sandra ; Rüfenacht, Véronique ; Nuoffer, Jean-Marc ; Häberle, Johannes

In: Journal of Inherited Metabolic Disease, 2015, vol. 38, no. 5, p. 815-827

Association mapping in biomedical time series via statistically significant shapelet mining

Bock, Christian ; Gumbsch, Thomas ; Moor, Michael ; Rieck, Bastian ; Roqueiro, Damian ; Borgwardt, Karsten

In: Bioinformatics, 2018, vol. 34, no. 13, p. i438-i446

Embodied neurology: an integrative framework for neurological disorders

Freund, Patrick ; Friston, Karl ; Thompson, Alan J. ; Stephan, Klaas E. ; Ashburner, John ; Bach, Dominik R. ; Nagy, Zoltan ; Helms, Gunther ; Draganski, Bogdan ; Mohammadi, Siawoosh ; Schwab, Martin E. ; Curt, Armin ; Weiskopf, Nikolaus

In: Brain, 2016, vol. 139, no. 6, p. 1855-1861

Ex vivo differential phase contrast and magnetic resonance imaging for characterization of human carotid atherosclerotic plaques

Meletta, Romana ; Borel, Nicole ; Stolzmann, Paul ; Astolfo, Alberto ; Klohs, Jan ; Stampanoni, Marco ; Rudin, Markus ; Schibli, Roger ; Krämer, Stefanie ; Müller Herde, Adrienne

In: The International Journal of Cardiovascular Imaging, 2015, vol. 31, no. 7, p. 1425-1434

Characterization and review of MTHFD1 deficiency: four new patients, cellular delineation and response to folic and folinic acid treatment

Burda, P. ; Kuster, A. ; Hjalmarson, O. ; Suormala, T. ; Bürer, C. ; Lutz, S. ; Roussey, G. ; Christa, L. ; Asin-Cayuela, J. ; Kollberg, G. ; Andersson, B. ; Watkins, D. ; Rosenblatt, D. ; Fowler, B. ; Holme, E. ; Froese, D. ; Baumgartner, M.

In: Journal of Inherited Metabolic Disease, 2015, vol. 38, no. 5, p. 863-872

The Swiss Transplant Cohort Study: Lessons from the First 6Years

Berger, Christoph ; Bochud, Pierre-Yves ; Boggian, Katja ; Cusini, Alexia ; Egli, Adrian ; Garzoni, Christian ; Hirsch, Hans ; Hoffmann, Matthias ; Khanna, Nina ; Manuel, Oriol ; Meylan, Pascal ; Nadal, David ; van Delden, Christian ; Weisser, Maja ; Mueller, Nicolas

In: Current Infectious Disease Reports, 2015, vol. 17, no. 6, p. 1-5

Structure and function analysis of an antibody recognizing all influenza A subtypes

Kallewaard, Nicole L. ; Corti, Davide ; Collins, Patrick J. ; Neu, Ursula ; McAuliffe, Josephine M. ; Benjamin, Ebony ; Wachter-Rosati, Leslie ; Palmer-Hill, Frances J. ; Yuan, Andy Q. ; Walker, Philip A. ; Vorlaender, Matthias K. ; Bianchi, Siro ; Guarino, Barbara ; De Marco, Anna ; Vanzetta, Fabrizia ; Agatic, Gloria ; Foglierini, Mathilde ; Pinna, Debora ; Fernandez-Rodriguez, Blanca ; Fruehwirth, Alexander ; Silacci, Chiara ; Ogrodowicz, Roksana W. ; Martin, Stephen R. ; Sallusto, Federica ; Suzich, JoAnn A. ; Lanzavecchia, Antonio ; Zhu, Qing ; Gamblin, Steven J. ; Skehel, John J.

In: Cell, 2016, vol. 166, no. 3, p. 596-608

Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody (mAb), MEDI8852, effectively reacting with all influenza A hemagglutinin (HA) subtypes. MEDI8852 uses the heavy-chain VH6-1 gene and has higher potency and breadth when...

A LAIR-1 insertion creates broadly reactive antibodies against malaria variant antigens

Tan, Joshua ; Pieper, Kathrin ; Piccoli, Luca ; Abdi, Abdirahman ; Tully, Claire Maria ; Foglierini Perez, Mathilde ; Geiger, Roger ; Jarrossay, David ; Maina Ndungu, Francis ; Wambua, Juliana ; Bejon, Philip ; Silacci Fregni, Chiara : Institute for Research in Biomedicine (IRB), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland ; Fernandez-Rodriguez, Blanca ; Barbieri, Sonia ; Bianchi, Siro ; Marsh, Kevin ; Thathy, Vandana ; Corti, Davide ; Sallusto, Federica ; Bull, Peter ; Lanzavecchia, Antonio

In: Nature, 2016, vol. 529, p. 25 p

Plasmodium falciparum antigens expressed on the surface of infected erythrocytes are important targets of naturally acquired immunity against malaria, but their high number and variability provide the pathogen with a powerful means of escape from host antibodies1,2,3,4. Although broadly reactive antibodies against these antigens could be useful as therapeutics and in vaccine design, their...

Improvement of DNA vector delivery of DOTAP lipoplexes by short-chain aminolipids

Buck, Jonas ; Mueller, Dennis ; Mettal, Ute ; Ackermann, Miriam ; Grisch-Chan, Hiu Man ; Thöny, Beat ; Zumbuehl, Andreas ; Huwyler, Jörg ; Witzigmann, Dominik

In: ACS Omega, 2020, vol. 5, no. 38, p. 24724–24732

Cellular delivery of DNA vectors for the expression of therapeutic proteins is a promising approach to treat monogenic disorders or cancer. Significant efforts in a preclinical and clinical setting have been made to develop potent nonviral gene delivery systems based on lipoplexes composed of permanently cationic lipids. However, transfection efficiency and tolerability of such systems are in...

Structural basis for broad HIV-1 neutralization by the MPER-specific human broadly neutralizing antibody LN01

Pinto, Dora ; Fenwick, Craig ; Caillat, Christophe ; Silacci, Chiara ; Guseva, Serafima ; Dehez, François ; Chipot, Christophe ; Barbieri, Sonia ; Minola, Andrea ; Jarrossay, David ; Tomaras, Georgia D. ; Shen, Xiaoying ; Riva, Agostino ; Tarkowski, Maciej ; Schwartz, Olivier ; Bruel, Timothée ; Dufloo, Jérémy ; Seaman, Michael S. ; Montefiori, David C. ; Lanzavecchia, Antonio ; Corti, Davide ; Pantaleo, Giuseppe ; Weissenhorn, Winfried

In: Cell host & microbe, 2019, vol. 26, no. 5, p. p. 623-637.e8

Potent and broadly neutralizing antibodies (bnAbs) are the hallmark of HIV-1 protection by vaccination. The membrane-proximal external region (MPER) of the HIV-1 gp41 fusion protein is targeted by the most broadly reactive HIV-1 neutralizing antibodies. Here, we examine the structural and molecular mechansims of neutralization by anti-MPER bnAb, LN01, which was isolated from lymph-node-derived...