In: Journal of Inherited Metabolic Disease, 2015, vol. 38, no. 5, p. 815-827
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In: Bioinformatics, 2018, vol. 34, no. 13, p. i438-i446
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In: Brain, 2016, vol. 139, no. 6, p. 1855-1861
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In: The International Journal of Cardiovascular Imaging, 2015, vol. 31, no. 7, p. 1425-1434
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In: Journal of Inherited Metabolic Disease, 2015, vol. 38, no. 5, p. 863-872
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In: Current Infectious Disease Reports, 2015, vol. 17, no. 6, p. 1-5
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In: Cell, 2016, vol. 166, no. 3, p. 596-608
Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody (mAb), MEDI8852, effectively reacting with all influenza A hemagglutinin (HA) subtypes. MEDI8852 uses the heavy-chain VH6-1 gene and has higher potency and breadth when...
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In: Nature, 2016, vol. 529, p. 25 p
Plasmodium falciparum antigens expressed on the surface of infected erythrocytes are important targets of naturally acquired immunity against malaria, but their high number and variability provide the pathogen with a powerful means of escape from host antibodies1,2,3,4. Although broadly reactive antibodies against these antigens could be useful as therapeutics and in vaccine design, their...
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In: ACS Omega, 2020, vol. 5, no. 38, p. 24724–24732
Cellular delivery of DNA vectors for the expression of therapeutic proteins is a promising approach to treat monogenic disorders or cancer. Significant efforts in a preclinical and clinical setting have been made to develop potent nonviral gene delivery systems based on lipoplexes composed of permanently cationic lipids. However, transfection efficiency and tolerability of such systems are in...
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In: Cell host & microbe, 2019, vol. 26, no. 5, p. p. 623-637.e8
Potent and broadly neutralizing antibodies (bnAbs) are the hallmark of HIV-1 protection by vaccination. The membrane-proximal external region (MPER) of the HIV-1 gp41 fusion protein is targeted by the most broadly reactive HIV-1 neutralizing antibodies. Here, we examine the structural and molecular mechansims of neutralization by anti-MPER bnAb, LN01, which was isolated from lymph-node-derived...
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