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Università della Svizzera italiana

Crossover or non-crossover outcomes : tailored processing of homologous recombination intermediates

Sanchez, Aurore ; Reginato, Giordano ; Cejka, Petr

In: Current opinion in genetics & development, 2021, vol. 71, p. 39-47

DNA breaks may arise accidentally in vegetative cells or in a programmed manner in meiosis. The usage of a DNA template makes homologous recombination potentially error-free, however, recombination is not always accurate. Cells possess a remarkable capacity to tailor processing of recombination intermediates to fulfill a particular need. Vegetatively growing cells aim to maintain genome...

Consortium of Swiss Academic Libraries

Randomization and the Gross-Pitaevskii Hierarchy

Sohinger, Vedran ; Staffilani, Gigliola

In: Archive for Rational Mechanics and Analysis, 2015, vol. 218, no. 1, p. 417-485

Université de Fribourg

Decrypting silicic magma/plug fragmentation at Azufral crater lake, Northern Andes : insights from fine to extremely fine ash morpho-chemistry

Pardo, Natalia ; Avellaneda, Jose D. ; Rausch, Juanita ; Jaramillo-Vogel, David ; Gutiérrez, Mariana ; Foubert, Anneleen

In: Bulletin of Volcanology, 2020, vol. 82, no. 12, p. 79

Azufral (SW Colombia) is a dangerous silicic volcano hosting a crater lake, which serves as an excellent example of an incipient plug disruption through phreatomagmatism. We studied the youngest succession of dilute pyroclastic density currents (PDCs) onlapping the north-eastern crater rim. Scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy was used to carry out an...

Université de Fribourg

Towards simpler and more transparent quantitative research reports

Vanhove, Jan

In: ITL - International Journal of Applied Linguistics

The average quantitative research report in applied linguistics is needlessly complicated. Articles with over fifty hypothesis tests are no exception, but despite such an onslaught of numbers, the patterns in the data often remain opaque to readers well-versed in quantitative methods, not to mention to colleagues, students, and non-academics without years of experience in navigating results...

Università della Svizzera italiana

The MRE11 complex : a versatile toolkit for the repair of broken DNA

Reginato, Giordano ; Cejka, Petr

In: DNA repair, 2020, vol. 91–92, no. July–August, p. 13 p

When DNA breaks, the ends need to be stabilized and processed to facilitate subsequent repair, which can occur by either direct but error-prone end-joining with another broken DNA molecule or a more accurate homology-directed repair by the recombination machinery. At the same time, the presence of broken DNA triggers a signaling cascade that regulates the repair events and cellular progression...

Università della Svizzera italiana

Quality control mechanisms of protein biogenesis : proteostasis dies hard

Bergmann, Timothy Jan ; Brambilla Pisoni, Giorgia ; Molinari, Maurizio

In: AIMS biophysics, 2016, vol. 3, no. 4, p. 456-478

The biosynthesis of proteins entails a complex series of chemical reactions that transform the information stored in the nucleic acid sequence into a polypeptide chain that needs to properly fold and reach its functional location in or outside the cell. It is of no surprise that errors might occur that alter the polypeptide sequence leading to a non-functional proteins or that impede delivery...