Ergebnisse einschränken

Autoimmune hepatitis : serum autoantibodies in clinical practice

Terziroli Beretta-Piccoli, Benedetta ; Mieli Vergani, Giorgina ; Vergani, Diego

In: Clinical reviews in allergy & immunology, 2021, p. 14

Circulating autoantibodies are a key diagnostic tool in autoimmune hepatitis (AIH), being positive in 95% of the cases if tested according to dedicated guidelines issued by the International Autoimmune Hepatitis Group. They also allow the distinction between type 1 AIH, characterized by positive anti-nuclear and/or anti-smooth muscle antibody, and type 2 AIH, characterized by positive...

Le malattie autoimmuni di fegato nell’adulto = Maladies auto-immunes du foie chez l’adulte

Terziroli Beretta-Piccoli, Benedetta ; De Gottardi, Andrea ; Vergani, Diego ; Mieli-Vergani, Giorgina

In: Schweizer gastroenterologie, 2021, vol. 2, no. 2, p. 56-66

Die Autoimmunhepatitis ist eine chronische Entzündung der Leber, die in jedem Lebensal- ter auftreten kann. Bei dieser Erkrankung werden erhöhte Transaminasen und Im- munglobulin G-Werte, das Vorhandensein von Autoantikörpern und Grenzzonenhepatitis (Interface-Hepatitis) bei Leberbiopsie verzeichnet. Die Therapie mit Steroiden zeigt sehr gute Ergebnisse. Wird die Krankheit nicht behandelt,...

Narcolepsy-Associated HLA Class I Alleles Implicate Cell-Mediated Cytotoxicity

Tafti, Mehdi ; Lammers, Gert J. ; Dauvilliers, Yves ; Overeem, Sebastiaan ; Mayer, Geert ; Nowak, Jacek ; Pfister, Corinne ; Dubois, Valérie ; Eliaou, Jean-François ; Eberhard, Hans-Peter ; Liblau, Roland ; Wierzbicka, Aleksandra ; Geisler, Peter ; Bassetti, Claudio L. ; Mathis, Johannes ; Lecendreux, Michel ; Khatami, Ramin ; Heinzer, Raphaël ; Haba-Rubio, José ; Feketeova, Eva ; Baumann, Christian R. ; Kutalik, Zoltán ; Tiercy, Jean-Marie

In: Sleep, 2016, vol. 39, no. 3, p. 581-587

Traveling Slow Oscillations During Sleep: A Marker of Brain Connectivity in Childhood

Kurth, Salome ; Riedner, Brady A. ; Dean, Douglas C. ; O'Muircheartaigh, Jonathan ; Huber, Reto ; Jenni, Oskar G. ; Deoni, Sean C L. ; LeBourgeois, Monique K.

In: SLEEP, 2017, vol. 40, no. 9, p. -

FTY720 and two novel butterfly derivatives exert a general anti-inflammatory potential by reducing immune cell adhesion to endothelial cells through activation of S1P3 and phosphoinositide 3-kinase

Imeri, Faik ; Blanchard, Olivier ; Jenni, Aurelio ; Schwalm, Stephanie ; Wünsche, Christin ; Zivkovic, Aleksandra ; Stark, Holger ; Pfeilschifter, Josef ; Huwiler, Andrea

In: Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, vol. 388, no. 12, p. 1283-1292

Genome-Wide Transcriptional Profiling and Structural Magnetic Resonance Imaging in the Maternal Immune Activation Model of Neurodevelopmental Disorders

Richetto, Juliet ; Chesters, Robert ; Cattaneo, Annamaria ; Labouesse, Marie A. ; Gutierrez, Ana Maria Carrillo ; Wood, Tobias C. ; Luoni, Alessia ; Meyer, Urs ; Vernon, Anthony ; Riva, Marco A.

In: Cerebral Cortex, 2017, vol. 27, no. 6, p. 3397-3413

The role of the acquired immune response in systemic sclerosis

Chizzolini, Carlo ; Boin, Francesco

In: Seminars in Immunopathology, 2015, vol. 37, no. 5, p. 519-528

DNA (hydroxy)methylation in T helper lymphocytes

Monticelli, Silvia

In: Trends in biochemical sciences, 2019, vol. 44, no. 7, p. 589-598

Upon recognition of an antigen, the differentiation of antigen-inexperienced naïve T lymphocytes into subsets able to effectively coordinate host defense is controlled by a network of transcription factors and regulatory molecules. In the cell nucleus, these factors act in the context of epigenetic modifications that influence DNA accessibility and ultimately gene expression. This review...

Alimentation et maladies auto-immunes : existe-t-il des nutriments dont les effets sur la modulation de l'inflammation ou l'immunité auraient été démontrés sur plusieurs maladies auto-immunes différentes ? : travail de Bachelor

Grimm, Djamila ; Parel, Nicolas

Mémoire de bachelor : Haute école de santé Genève, 2019.

Introduction : L’altération de la capacité du système immunitaire à reconnaître le soi du non soi entraîne une réaction auto immune. Les maladies auto immunes sont des pathologies inflammatoires chroniques. Elles détériorent profondément la qualité de vie des personnes qui en sont atteintes. Il n’existe actuellement aucun traitement curatif pour ces pathologies. Les effets...

Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis

Hu, Dan ; Notarbartolo, Samuele ; Croonenborghs, Tom ; Patel, Bonny ; Cialic, Ron ; Yang, Tun-Hsiang ; Aschenbrenner, Dominik ; Andersson, Karin M. ; Gattorno, Marco ; Pham, Minh ; Kivisakk, Pia ; Pierre, Isabelle V. ; Lee, Youjin ; Kiani, Karun ; Bokarewa, Maria ; Tjon, Emily ; Pochet, Nathalie ; Sallusto, Federica ; Kuchroo, Vijay K. ; Weiner, Howard L.

In: Nature communications, 2017, vol. 8, p. 1600

We have previously reported the molecular signature of murine pathogenic TH17 cells that induce experimental autoimmune encephalomyelitis (EAE) in animals. Here we show that human peripheral blood IFN-γ+IL-17+ (TH1/17) and IFN-γ−IL-17+ (TH17) CD4+ T cells display distinct transcriptional profiles in high-throughput transcription analyses. Compared to TH17 cells, TH1/17 cells have gene...