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Consortium of Swiss Academic Libraries

Measuring Populist Attitudes on Three Dimensions

Schulz, Anne ; Müller, Philipp ; Schemer, Christian ; Wirz, Dominique Stefanie ; Wettstein, Martin ; Wirth, Werner

In: International Journal of Public Opinion Research, 2018, vol. 30, no. 2, p. 316-326

Université de Fribourg

Low prevalence of lactase persistence in bronze age europe indicates ongoing strong selection over the last 3,000 years

Burger, Joachim ; Link, Vivian ; Blöcher, Jens ; Schulz, Anna ; Sell, Christian ; Pochon, Zoé ; Diekmann, Yoan ; Žegarac, Aleksandra ; Hofmanová, Zuzana ; Winkelbach, Laura ; Reyna-Blanco, Carlos S. ; Bieker, Vanessa ; Orschiedt, Jörg ; Brinker, Ute ; Scheu, Amelie ; Leuenberger, Christoph ; Bertino, Thomas S. ; Bollongino, Ruth ; Lidke, Gundula ; Stefanović, Sofija ; Jantzen, Detlef ; Kaiser, Elke ; Terberger, Thomas ; Thomas, Mark G. ; Veeramah, Krishna R. ; Wegmann, Daniel

In: Current Biology, 2020, p. -

Lactase persistence (LP), the continued expression of lactase into adulthood, is the most strongly selected single gene trait over the last 10,000 years in multiple human populations. It has been posited that the primary allele causing LP among Eurasians, rs4988235-A [1], only rose to appreciable frequencies during the Bronze and Iron Ages [2, 3], long after humans started consuming milk from...

Université de Fribourg

EEF1A1 deacetylation enables transcriptional activation of remyelination

Duman, Mert ; Vaquié, Adrien ; Nocera, Gianluigi ; Heller, Manfred ; Stumpe, Michael ; Sankar, Devanarayanan Siva ; Dengjel, Jörn ; Meijer, Dies ; Yamaguchi, Teppei ; Matthias, Patrick ; Zeis, Thomas ; Schaeren-Wiemers, Nicole ; Hayoz, Antoinette ; Ruff, Sophie ; Jacob, Claire

In: Nature Communications, 2020, vol. 11, no. 1, p. 3420

Remyelination of the peripheral and central nervous systems (PNS and CNS, respectively) is a prerequisite for functional recovery after lesion. However, this process is not always optimal and becomes inefficient in the course of multiple sclerosis. Here we show that, when acetylated, eukaryotic elongation factor 1A1 (eEF1A1) negatively regulates PNS and CNS remyelination. Acetylated eEF1A1...

Université de Fribourg

Resonance raman optical activity shows unusual structural sensitivity for systems in resonance with multiple excited states: vitamin B12 case

Machalska, Ewa ; Zajac, Grzegorz ; Gruca, Anna ; Zobi, Fabio ; Baranska, Malgorzata ; Kaczor, Agnieszka

In: The Journal of Physical Chemistry Letters, 2020, vol. 11, no. 13, p. 5037–5043

In this work, cobalamins with different upper axial substituents and a cobalamin derivative with a ring modification were studied using chiroptical spectroscopies, in particular resonance Raman optical activity (RROA), to shed light on the influence of structural modifications on RROA spectra in these strongly chiral systems in resonance with multiple excited states at 532 nm excitation. We...