Ergebnisse einschränken

Involvement of long non-coding RNAs in beta cell failure at the onset of type 1 diabetes in NOD mice

Motterle, Anna ; Gattesco, Sonia ; Caille, Dorothée ; Meda, Paolo ; Regazzi, Romano

In: Diabetologia, 2015, vol. 58, no. 8, p. 1827-1835

Role of islet microRNAs in diabetes: which model for which question?

Guay, Claudiane ; Regazzi, Romano

In: Diabetologia, 2015, vol. 58, no. 3, p. 456-463

Targeting GLP-1 receptors for repeated magnetic resonance imaging differentiates graded losses of pancreatic beta cells in mice

Vinet, Laurent ; Lamprianou, Smaragda ; Babič, Andrej ; Lange, Norbert ; Thorel, Fabrizio ; Herrera, Pedro ; Montet, Xavier ; Meda, Paolo

In: Diabetologia, 2015, vol. 58, no. 2, p. 304-312

Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia

Grimaldi, Mariagrazia ; Karaca, Melis ; Latini, Livia ; Brioudes, Estelle ; Schalch, Thomas ; Maechler, Pierre

In: Human Molecular Genetics, 2017, vol. 26, no. 18, p. 3453-3465

GLUT2, glucose sensing and glucose homeostasis

Thorens, Bernard

In: Diabetologia, 2015, vol. 58, no. 2, p. 221-232

miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development

Latreille, Mathieu ; Herrmanns, Karolin ; Renwick, Neil ; Tuschl, Thomas ; Malecki, Maciej ; McCarthy, Mark ; Owen, Katharine ; Rülicke, Thomas ; Stoffel, Markus

In: Journal of Molecular Medicine, 2015, vol. 93, no. 10, p. 1159-1169

Ins1 Cre knock-in mice for beta cell-specific gene recombination

Thorens, Bernard ; Tarussio, David ; Maestro, Miguel ; Rovira, Meritxell ; Heikkilä, Eija ; Ferrer, Jorge

In: Diabetologia, 2015, vol. 58, no. 3, p. 558-565

Effects of the poly(ADP-ribose) polymerase inhibitor olaparib in cerulein-induced pancreatitis

Ahmad, Akbar ; Haas De Mello, Aline ; Szczesny, Bartosz ; Törö, Gábor ; Marcatti, Michela ; Druzhyna, Nadiya ; Liaudet, Lucas ; Tarantini, Stefano ; Salomao, Reinaldo ; Garcia Soriano, Francisco ; Szabo, Csaba

In: Shock, 2020, vol. 53, no. 5, p. 653–665

Objective: Activation of the constitutive nuclear and mitochondrial enzyme poly (ADP- ribose) polymerase (PARP) has been implicated in the pathogenesis of cell dysfunction, inflammation, and organ failure in various forms of critical illness. The objective of our study was to evaluate the efficacy and safety of the clinically approved PARP inhibitor olaparib in an experimental model of...

Modulation of calretinin expression in human mesothelioma cells reveals the implication of the fak and wnt signaling pathways in conferring chemoresistance towards cisplatin

Wörthmüller, Janine ; Salicio, Valérie ; Oberson, Anne ; Blum, Walter ; Schwaller, Beat

In: International Journal of Molecular Sciences, 2019, vol. 20, no. 21, p. 5391

Malignant mesothelioma (MM) is an aggressive asbestos-linked neoplasm, characterized by dysregulation of signaling pathways. Due to intrinsic or acquired chemoresistance, MM treatment options remain limited. Calretinin is a Ca2+-binding protein expressed during MM tumorigenesis that activates the FAK signaling pathway, promoting invasion and epithelial-to-mesenchymal transition. Constitutive...

Breast cancer stem cells with tumor- versus metastasis-initiating capacities are modulated by TGFBR1 inhibition

Fico, Flavia ; Bousquenaud, Mélanie ; Rüegg, Curzio ; Santamaria-Martínez, Albert

In: Stem Cell Reports, 2019, vol. 13, no. 1, p. 1–9

Cancer stem cells (CSCs) are defined by their ability to regenerate a tumor upon transplantation. However, it is not yet clear whether tumors contain a single CSC population or different subsets of cells with mixed capacities for initiating primary and secondary tumors. Using two different identification strategies, we studied the overlap between metastatic stem cells and tumor-initiating...