In: Cellular and Molecular Bioengineering, 2015, vol. 8, no. 1, p. 160-177
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In: Advanced Functional Materials, 2020, p. 2002630
Nanoparticle adsorption to substrates pose a unique challenge to understand uptake mechanisms as it involves the organization of complex cytoskeletal components by cells to perform endocytosis/phagocytosis. In particular, it is not well‐understood from a cell mechanics perspective how the adhesion of particles on substrate will influence the ease of material clearance. By using a particle...
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In: Biology Open, 2020, vol. 9, no. 6, p. bio053470
Members of the CAP/SCP/TAPS superfamily have been implicated in many different physiological processes, including pathogen defense, sperm maturation and fertilization. The mode of action of this class of proteins, however, remains poorly understood. The genome of Saccharomyces cerevisiae encodes three CAP superfamily members, Pry1-3. We have previously shown that Pry1 function is required...
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In: Autophagy, 2019, vol. 0, no. 0, p. 1–14
Macroautophagy/autophagy, a highly conserved dynamic process, is one of the major degradative pathways in cells. So far, over 40 autophagy-related (ATG) genes have been identified in Saccharomyces cerevisiae, most of which have homologs in more complex eukaryotes. Autophagy plays a crucial role in cell survival and maintenance, and its dysfunction is related to various diseases, indicating...
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In: Plos one, 2011, vol. 6, no. 10, p. e26133
Mast cells have essential effector and immunoregulatory functions in IgE-associated allergic disorders and certain innate and adaptive immune responses, but the role of miRNAs in regulating mast cell functions is almost completely unexplored. To examine the role of the activation-induced miRNA miR-221 in mouse mast cells, we developed robust lentiviral systems for miRNA overexpression and...
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In: Annals of Biomedical Engineering, 2014, vol. 42, no. 6, p. 1143-1144
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In: Immunological Reviews, 2019, vol. 289, no. 1, p. 232–249
CD8+ T cells have evolved as one of the most motile mammalian cell types, designed to continuously scan peptide–major histocompatibility complexes class I on the surfaces of other cells. Chemoattractants and adhesion molecules direct CD8+ T‐cell homing to and migration within secondary lymphoid organs, where these cells colocalize with antigen‐presenting dendritic cells in confined...
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In: Developmental Cell, 2018, vol. 47, no. 6, p. 741-757.e8
Podocytes, highly specialized epithelial cells, build the outer part of the kidney filtration barrier and withstand high mechanical forces through a complex network of cellular protrusions. Here, we show that Arp2/3-dependent actin polymerization controls actomyosin contractility and focal adhesion maturation of podocyte protrusions and thereby regulates formation, maintenance, and capacity...
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In: Apoptosis, 2007, vol. 12, no. 2, p. 363-374
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In: Journal of Muscle Research & Cell Motility, 2003, vol. 24, no. 2-3, p. 219-249
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