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Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells

Grünig, David ; Felser, Andrea ; Duthaler, Urs ; Bouitbir, Jamal ; Krähenbühl, Stephan

In: Toxicological Sciences, 2018, vol. 164, no. 2, p. 477-488

Response to chronic sleep restriction, extension, and subsequent total sleep deprivation in humans: adaptation or preserved sleep homeostasis?

Skorucak, Jelena ; Arbon, Emma L. ; Dijk, Derk-Jan ; Achermann, Peter

In: SLEEP, 2018, vol. 41, no. 7, p. -

Differential cellular expression of organic anion transporting peptides OATP1A2 and OATP2B1 in the human retina and brain: implications for carrier-mediated transport of neuropeptides and neurosteriods in the CNS

Gao, Bo ; Vavricka, Stephan ; Meier, Peter ; Stieger, Bruno

In: Pflügers Archiv - European Journal of Physiology, 2015, vol. 467, no. 7, p. 1481-1493

Monoamine Transporter and Receptor Interaction Profiles in Vitro Predict Reported Human Doses of Novel Psychoactive Stimulants and Psychedelics

Luethi, Dino ; Liechti, Matthias E.

In: International Journal of Neuropsychopharmacology, 2018, vol. 21, no. 10, p. 926-931

Deviant Processing in the Primary Somatosensory Cortex

Musall, Simon ; Haiss, Florent ; Weber, Bruno ; von der Behrens, Wolfger

In: Cerebral Cortex, 2017, vol. 27, no. 1, p. 863-876

Long-term In Vivo Calcium Imaging of Astrocytes Reveals Distinct Cellular Compartment Responses to Sensory Stimulation

Stobart, Jillian L. ; Ferrari, Kim David ; Barrett, Matthew J P. ; Stobart, Michael J. ; Looser, Zoe J. ; Saab, Aiman S. ; Weber, Bruno

In: Cerebral Cortex, 2018, vol. 28, no. 1, p. 184-198

Using dried blood spots to facilitate therapeutic drug monitoring of antiretroviral drugs in resource-poor regions

Duthaler, Urs ; Berger, Benjamin ; Erb, Stefan ; Battegay, Manuel ; Letang, Emili ; Gaugler, Stefan ; Natamatungiro, Alex ; Mnzava, Dorcas ; Donzelli, Massimiliano ; Krähenbühl, Stephan ; Haschke, Manuel

In: Journal of Antimicrobial Chemotherapy, 2018, vol. 73, no. 10, p. 2729-2737

Cystathionine-β-synthase: molecular regulation and pharmacological inhibition

Zuhra, Karim ; Augsburger, Fiona ; Majtan, Tomas ; Szabo, Csaba

In: Biomolecules, 2020, vol. 10, no. 5, p. 697

Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration pathway, is an important mammalian enzyme in health and disease. Its biochemical functions under physiological conditions include the metabolism of homocysteine (a cytotoxic molecule and cardiovascular risk factor) and the generation of hydrogen sulfide (H2S), a gaseous biological mediator with...

Overproduction of H2S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome

Panagaki, Theodora ; Randi, Elisa B. ; Augsburger, Fiona ; Szabo, Csaba

In: Proceedings of the National Academy of Sciences, 2019, p. 201911895

Down syndrome (DS) is associated with significant perturbances in mitochondrial function. Here we tested the hypothesis that the suppression of mitochondrial electron transport in DS cells is due to high expression of cystathionine-β-synthase (CBS) and subsequent overproduction of the gaseous transmitter hydrogen sulfide (H2S). Fibroblasts from DS individuals showed higher CBS expression...

Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice

Morand, Réjane ; Bouitbir, Jamal ; Felser, Andrea ; Hench, Jürgen ; Handschin, Christoph ; Frank, Stephan ; Krähenbühl, Stephan

In: European Journal of Nutrition, 2014, vol. 53, no. 6, p. 1313-1325