Ergebnisse einschränken

Multi-scale Structure Formation and Dynamics in Cosmic Plasmas

Balogh, A. ; Bykov, A. ; Eastwood, J. ; Kaastra, J.

In: Space Science Reviews, 2015, vol. 188, no. 1-4, p. 1-2

Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells

Grünig, David ; Felser, Andrea ; Duthaler, Urs ; Bouitbir, Jamal ; Krähenbühl, Stephan

In: Toxicological Sciences, 2018, vol. 164, no. 2, p. 477-488

Differential cellular expression of organic anion transporting peptides OATP1A2 and OATP2B1 in the human retina and brain: implications for carrier-mediated transport of neuropeptides and neurosteriods in the CNS

Gao, Bo ; Vavricka, Stephan ; Meier, Peter ; Stieger, Bruno

In: Pflügers Archiv - European Journal of Physiology, 2015, vol. 467, no. 7, p. 1481-1493

Monoamine Transporter and Receptor Interaction Profiles in Vitro Predict Reported Human Doses of Novel Psychoactive Stimulants and Psychedelics

Luethi, Dino ; Liechti, Matthias E.

In: International Journal of Neuropsychopharmacology, 2018, vol. 21, no. 10, p. 926-931

Using dried blood spots to facilitate therapeutic drug monitoring of antiretroviral drugs in resource-poor regions

Duthaler, Urs ; Berger, Benjamin ; Erb, Stefan ; Battegay, Manuel ; Letang, Emili ; Gaugler, Stefan ; Natamatungiro, Alex ; Mnzava, Dorcas ; Donzelli, Massimiliano ; Krähenbühl, Stephan ; Haschke, Manuel

In: Journal of Antimicrobial Chemotherapy, 2018, vol. 73, no. 10, p. 2729-2737

Hepatocellular Toxicity of Imidazole and Triazole Antimycotic Agents

Haegler, Patrizia ; Joerin, Lorenz ; Krähenbühl, Stephan ; Bouitbir, Jamal

In: Toxicological Sciences, 2017, vol. 157, no. 1, p. 183-195

A twist in the ABC : regulation of ABC transporter trafficking and transport by FK506‐binding proteins

Geisler, Markus ; Hegedűs, Tamás

In: FEBS Letters, 2020, vol. 594, no. 23, p. 3986-4000

Post-transcriptional regulation of ATP-binding cassette (ABC) proteins has been so far shown to encompass protein phosphorylation, maturation, and ubiquitination. Yet, recent accumulating evidence implicates FK506-binding proteins (FKBPs), a type of peptidylprolyl cis–trans isomerase (PPIase) proteins, in ABC transporter regulation. In this perspective article, we summarize current knowledge on...

An ATP-dependent partner switch links flagellar C-ring assembly with gene expression

Blagotinsek, Vitan ; Schwan, Meike ; Steinchen, Wieland ; Mrusek, Devid ; Hook, John C. ; Rossmann, Florian ; Freibert, Sven A. ; Kratzat, Hanna ; Murat, Guillaume ; Kressler, Dieter ; Beckmann, Roland ; Beeby, Morgan ; Thormann, Kai M. ; Bange, Gert

In: Proceedings of the National Academy of Sciences, 2020, vol. 117, no. 34, p. 20826–20835

Bacterial flagella differ in their number and spatial arrangement. In many species, the MinD-type ATPase FlhG (also YlxH/FleN) is central to the numerical control of bacterial flagella, and its deletion in polarly flagellated bacteria typically leads to hyperflagellation. The molecular mechanism underlying this numerical control, however, remains enigmatic. Using the model species Shewanella...

Auxin-transporting ABC transporters are defined by a conserved D/E-P motif regulated by a prolylisomerase

Hao, Pengchao ; Xia, Jian ; Liu, Jie ; Donato, Martin Di ; Pakula, Konrad ; Bailly, Aurélien ; Jasinski, Michal ; Geisler, Markus

In: Journal of Biological Chemistry, 2020, vol. 295, no. 37, p. 13094–13105

The plant hormone auxin must be transported throughout plants in a cell-to-cell manner to affect its various physiological functions. ABCB transporters are critical for this polar auxin distribution, but the regulatory mechanisms controlling their function is not fully understood. The auxin transport activity of ABCB1 was suggested to be regulated by a physical interaction with FKBP42/Twisted...

Overproduction of H2S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome

Panagaki, Theodora ; Randi, Elisa B. ; Augsburger, Fiona ; Szabo, Csaba

In: Proceedings of the National Academy of Sciences, 2019, p. 201911895

Down syndrome (DS) is associated with significant perturbances in mitochondrial function. Here we tested the hypothesis that the suppression of mitochondrial electron transport in DS cells is due to high expression of cystathionine-β-synthase (CBS) and subsequent overproduction of the gaseous transmitter hydrogen sulfide (H2S). Fibroblasts from DS individuals showed higher CBS expression...