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Université de Fribourg

Networking and Storage : The Next Computing Elements in Exascale Systems?

Lerner, Alberto ; Hussein, Rana ; Ryser, André ; Lee, Sangjin ; Cudré-Mauroux, Philippe

In: IEEE Data Engineering Bulletin, 2020, vol. 43, no. 1, p. 60-71

Many large computer clusters offer alternative computing elements in addition to general-purpose CPUs. GPU and FPGAs are very common choices. Two emerging technologies can further widen the options in that context: in-network computing (INC) and near-storage processing (NSP). These technologies support computing over data that is in transit between nodes or inside the storage stack,...

Université de Fribourg

Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure

Zoni, Valeria ; Khaddaj, Rasha ; Lukmantara, Ivan ; Shinoda, Wataru ; Hongyuan, Yang ; Schneiter, Roger ; Vanni, Stefano

In: Proceedings of the National Academy of Sciences, 2021, vol. 118, no. 10, p. e2017205118

Lipid droplets (LDs) are intracellular organelles responsible for lipid storage, and they emerge from the endoplasmic reticulum (ER) upon the accumulation of neutral lipids, mostly triglycerides (TG), between the two leaflets of the ER membrane. LD biogenesis takes place at ER sites that are marked by the protein seipin, which subsequently recruits additional proteins to catalyze LD formation....

Université de Fribourg

Lipid droplet biogenesis from specialized ER subdomains

Choudhary, Vineet ; Schneiter, Roger

In: Microbial Cell, 2020, vol. 7, no. 8, p. 218–221

Lipid droplets (LDs) are cellular compartments dedicated to the storage of metabolic energy in the form of neutral lipids, commonly known as “fat”. The biogenesis of LDs takes place in the endoplasmic reticulum (ER), but its spatial and temporal organization is poorly understood. How exactly sites of LD formation are selected and the succession of proteins and lipids needed to mediate...

Université de Fribourg

Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis

Choudhary, Vineet ; El Atab, Ola ; Mizzon, Giulia ; Prinz, William A. ; Schneiter, Roger

In: Journal of Cell Biology, 2020, vol. 219, no. 7, p. -

Lipid droplets (LDs) are fat storage organelles that originate from the endoplasmic reticulum (ER). Relatively little is known about how sites of LD formation are selected and which proteins/lipids are necessary for the process. Here, we show that LDs induced by the yeast triacylglycerol (TAG)-synthases Lro1 and Dga1 are formed at discrete ER subdomains defined by seipin (Fld1), and a...