In: BioMetals, 2015, vol. 28, no. 3, p. 521-528
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In: Sleep, 2016, vol. 39, no. 3, p. 589-601
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In: Diabetologia, 2015, vol. 58, no. 2, p. 221-232
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In: Toxicological Sciences, 2017, vol. 160, no. 2, p. 230-243
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In: Diabetologia, 2015, vol. 58, no. 3, p. 558-565
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In: Current Biology, 2020, vol. 30, no. 19, p. 3775-3787.e7
Sphingolipids play important roles in physiology and cell biology, but a systematic examination of their functions is lacking. We performed a genome-wide CRISPRi screen in sphingolipid-depleted human cells and identified hypersensitive mutants in genes of membrane trafficking and lipid biosynthesis, including ether lipid synthesis. Systematic lipidomic analysis showed a coordinate regulation...
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In: International Journal of Molecular Sciences, 2020, vol. 21, no. 9, p. 3347
Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self and non-self through cell-intrinsic and cell-extrinsic mechanisms. Peripheral Tregs survival and clonal expansion largely depend on IL-2 and access to co-stimulatory signals such as CD28. Engagement of tumor necrosis factor receptor (TNFR) superfamily members, in particular TNFR2 and DR3, contribute to promote...
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In: Basic Research in Cardiology, 2014, vol. 109, no. 1, p. 1-15
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In: Cellular and Molecular Life Sciences, 2014, vol. 71, no. 8, p. 1453-1467
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In: Seminars in Immunopathology, 2014, vol. 36, no. 1, p. 73-91
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