Université de Fribourg

Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance

Stolp, Bettina ; Thelen, Flavian ; Ficht, Xenia ; Altenburger, Lukas M. ; Ruef, Nora ; Inavalli, V. V. G. Krishna ; Germann, Philipp ; Page, Nicolas ; Moalli, Federica ; Raimondi, Andrea ; Keyser, Kirsten A. ; Jafari, S. Morteza Seyed ; Barone, Francesca ; Dettmer, Matthias S. ; Merkler, Doron ; Iannacone, Matteo ; Sharpe, James ; Schlapbach, Christoph ; Fackler, Oliver T. ; Nägerl, U. Valentin ; Stein, Jens V.

In: Science Immunology, 2020, vol. 5, no. 46, p. eaaz4371

It is well established that tissue macrophages and tissue-resident memory CD8+ T cells (TRM) play important roles for pathogen sensing and rapid protection of barrier tissues. In contrast, the mechanisms by which these two cell types cooperate for homeostatic organ surveillance after clearance of infections is poorly understood. Here, we used intravital imaging to show that TRM dynamically...

Université de Fribourg

Hemozoin-catalyzed precipitation polymerization as an assay for malaria diagnosis

Rifaie-Graham, Omar ; Pollard, Jonas ; Raccio, Samuel ; Balog, Sandor ; Rusch, Sebastian ; Hernández-Castañeda, María Andrea ; Mantel, Pierre-Yves ; Beck, Hans-Peter ; Bruns, Nico

In: Nature Communications, 2019, vol. 10, no. 1, p. 1369

Methods to diagnose malaria are of paramount interest to eradicate the disease. Current methods have severe limitations, as they are either costly or not sensitive enough to detect low levels of parasitemia. Here we report an ultrasensitive, yet low- resource chemical assay for the detection and quantification of hemozoin, a biomarker of all Plasmodium species. Solubilized hemozoin catalyzes...

Université de Fribourg

Unequivocal signatures of the crossover to Anderson localization in realistic models of disordered quasi-one-dimensional materials

Lopez-Bezanilla, Alejandro ; Froufe-Pérez, Luis S. ; Roche, Stephan ; Sáenz, Juan José

In: Physical Review B, 2018, vol. 98, no. 23, p. 235423

The only unequivocal known criterion for single-parameter scaling Anderson localization relies on the knowledge of the full conductance statistics. To date, theoretical studies have been restricted to model systems with symmetric scatterers, hence lacking universality. We present an in-depth statistical study of conductance distributions P(g), in disordered ‘micrometer-long’ carbon...